BACKGROUND Exercise training is an important component of multidisciplinary heart failure management. However, the effects of aerobic training (AT) versus resistance training (RT) on cardiac function in patients with heart failure with reduced ejection fraction are not well defined. The aim of this study was to evaluate the impact of these exercise modalities on echocardiographic parameters. METHODS Participants with stable heart failure with reduced ejection fraction (ejection fraction < 50%) were randomized to 12 weeks of AT, RT, or untrained control. Exercise was performed at matched relative intensities of each training modality (50%-70% of maximum). Echocardiography and cardiopulmonary exercise testing were performed at baseline and after 12 weeks of training. RESULTS Thirty-eight participants were randomized, and 12 in each group completed the intervention (mean age, 61.5 ± 1.7 years; 89% men). Peak oxygen consumption increased from 14.5 ± 1.3 to 17.2 ± 1.6 ml · min-1 · kg-1 after AT and from 13.7 ± 1.2 to 16.4 ± 1.1 ml · min-1 · kg-1 after RT (P < .001 for both). In the AT group, there was a decrease in septal e' (from 0.052 ± 0.004 to 0.041 ± 0.004 m/sec) and increases in E/e' ratio (from 18.2 ± 3.1 to 23.8 ± 3.5), left atrial volume (from 86 ± 9 to 99 ± 10 mL), and right ventricular end-diastolic area (from 18 ± 1 to 20 ± 1 cm2; P < .05 for all), but these were unchanged in the control and RT groups. There were no significant changes in left ventricular diameters or volumes or right ventricular fractional area change after exercise. CONCLUSIONS There is a differential effect of AT versus RT on some echocardiographic parameters in patients with heart failure with reduced ejection fraction. AT was associated with evidence of worsening myocardial diastolic function, whereas this was not apparent after RT. Further studies are indicated to investigate the long-term clinical significance of these adaptations.

中文翻译：

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不同的运动训练方式对射血分数降低的心力衰竭患者的超声心动图测量结果的影响。

背景技术运动训练是多学科心力衰竭管理的重要组成部分。但是，对于射血分数降低的心力衰竭患者，有氧训练（AT）与抵抗训练（RT）对心功能的影响尚不明确。这项研究的目的是评估这些运动方式对超声心动图参数的影响。方法将具有稳定的心力衰竭且射血分数降低（射血分数<50％）的参与者随机分为12周的AT，RT或未经训练的对照。在每种训练方式的匹配相对强度下进行锻炼（最大值的50％-70％）。在基线和训练12周后进行超声心动图和心肺运动测试。结果38名参与者被随机分组​​，每组中有12人完成了干预（平均年龄为61.5±1.7岁；男性为89％）。峰值耗氧量在AT后从14.5±1.3升至17.2±1.6 ml·min-1·kg-1，从RT后从13.7±1.2增至16.4±1.1 ml·min-1·kg-1（两者的P <.001 ）。在AT组，间隔e'减少（从0.052±0.004到0.041±0.004 m / sec），E / e'比增加（从18.2±3.1到23.8±3.5），左心房容积（从86±9至99±10 mL）和右心室舒张末期面积（从18±1至20±1 cm2；对于所有患者，P <.05），但在对照组和RT组中，这些没有改变。运动后左心室的直径或体积或右心室的分数面积没有明显变化。结论在射血分数降低的心力衰竭患者中，AT与RT对某些超声心动图参数有不同的影响。AT与心肌舒张功能恶化的证据有关，而RT后这种现象并不明显。指出有进一步的研究来调查这些适应措施的长期临床意义。