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Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea
Journal of Natural Products ( IF 4.257 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.jnatprod.9b00149
Inés Castro, Nicolas Fabre, Sandra Bourgeade-Delmas, Nathalie Saffon, Chloé Gandini, Michel Sauvain, Denis Castillo, Geneviève Bourdy, Valérie Jullian

Six new secocycloartane glycosides (1–6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1–6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1–6 were also evaluated.
更新日期:2019-12-05

 

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