Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.

中文翻译：

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从秘鲁药用植物Cordia lutea的花朵中分离出的9,10-Seco-29-norcycloartane糖苷的结构表征和抗感染活性。

从Cordia lutea Lam花的乙醇提取物中分离出六种新的七环烷烷糖苷（1-6）。在生物测定指导的分馏基础上。通过应用NMR和MS数据分析以及对化合物1和2的X射线晶体学分析来确定它们的结构。化合物1-6代表9,10-seco-29-正环烷烷糖苷的第一个实例。这些化合物显示出显着的体外抗幽门螺杆菌活性，对大肠杆菌或铜绿假单胞菌均无活性。观察到针对金黄色葡萄球菌的5和6的显着活性。所有化合物均显示出对RAW 264.7细胞的弱细胞毒性。还评估了1-6的体外抗疟原虫和抗疟原虫活性。