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Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea.
Journal of Natural Products ( IF 3.779 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.jnatprod.9b00149
Inés Castro,Nicolas Fabre,Sandra Bourgeade-Delmas,Nathalie Saffon,Chloé Gandini,Michel Sauvain,Denis Castillo,Geneviève Bourdy,Valérie Jullian

Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.
更新日期:2019-12-05

 

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