The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N6-methyladenosine in the nervous system.

中文翻译：

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m6A 表观转录组：大脑发育和功能中的转录组可塑性。

表观转录组学领域研究了最近破译的基因表达调控形式，这种调控由类型和位点特异性 RNA 修饰介导。与表观遗传机制（通过 DNA 和组蛋白修饰发挥作用）所起的作用类似，表观转录组修饰参与控制神经系统发育和活动所需的微妙基因表达模式，对基础和高级大脑至关重要职能。在这里，我们描述了 N6-甲基腺苷（最普遍的内部 mRNA 修饰）的写入、擦除和读取所涉及的机制，以及 N6-甲基腺苷在神经系统中所起的新作用。