BACKGROUND Although several studies indicate the effects of diabetes type 2 on health-related quality of life (HRQoL) in female subjects, the related impact of the disease on HRQoL in their family members has rarely been the focus of the empirical research. In this study we aim to investigate associations between diabetes in women and the HRQoL in these women and their family members, using the structural equation modeling (SEM). METHODS This family-based study was conducted on 794 women (11.1% with diabetes) as well as their spouses and children who participated in the Tehran Lipid and Glucose Study (TLGS) from 2014 to 2016. Data on HRQoL were collected using the Iranian version of the Short-Form 12-Item Health Survey version 2 (SF-12v2) and the Pediatric Quality of Life Inventory version™ 4.0 (PedsQL). SEM was conducted to evaluate the network of associations among studied variables. Data were analyzed using IBM SPSS Statistics & AMOS version 23 software. RESULTS Mean age of women was 41.37 ± 5.32 years. Diabetes in women significantly affected their mental HRQoL (β = - 0.11, P < 0.01) but showed no significant direct associations with physical and mental HRQoL in their spouses or their children. However, poor mental HRQoL in women with diabetes was associated with decrease in both physical (β = - 0.02, P = 0.013) and mental (β = - 0.03, P < 0.01) HRQoL in their spouses and total HRQoL score in children (β = - 0.02, P < 0.01). CONCLUSIONS Among women with diabetes type 2, beyond its effect on their mental HRQoL per se, demonstrated a negative association with the self-assessment of health status in their spouses and children. Such familial consequences are mainly attributed to the negative effect of the disease on the mental rather than the physical HRQoL in women with diabetes.

中文翻译：

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妇女糖尿病与整个家庭健康相关的生活质量：结构方程模型。

背景技术尽管一些研究表明2型糖尿病对女性受试者健康相关生活质量（HRQoL）的影响，但疾病对其家庭成员HRQoL的相关影响很少成为经验研究的重点。在这项研究中，我们旨在使用结构方程模型（SEM）研究女性糖尿病与这些女性及其家庭成员的HRQoL之间的关联。方法这项基于家庭的研究是针对2014年至2016年参加德黑兰血脂和葡萄糖研究（TLGS）的794名妇女（11.1％患有糖尿病）及其配偶和子女进行的。HRQoL数据使用伊朗版本收集简短的12项健康调查版本2（SF-12v2）和小儿生活质量清单™4.0（PedsQL）的内容。进行了SEM评估研究变量之间的关联网络。使用IBM SPSS Statistics＆AMOS 23版软件分析数据。结果女性平均年龄为41.37±5.32岁。女性糖尿病严重影响了她们的心理HRQoL（β=-0.11，P <0.01），但未显示与配偶或子女的身心HRQoL有显着的直接关联。然而，糖尿病女性的心理HRQoL差与配偶的身体（β=-0.02，P = 0.013）和精神（β=-0.03，P <0.01）的心理HRQoL降低以及儿童的总HRQoL分数（β =-0.02，P <0.01）。结论在2型糖尿病妇女中，除了其对心理HRQoL的影响外，还显示出其配偶和孩子的健康状况自我评估呈负相关。