In the present study, a series of thiodihydropyrimidine derivatives were synthesized from different substituted aromatic aldehydes, ethyl acetoacetate, and urea/thiourea using a bimetallic TUD‐1 catalyst. The structures of all the synthesized compounds were characterized by melting point determination, thin layer chromatography (TLC), infrared (IR), ¹HNMR, and ¹³C‐NMR values. All the synthesized compounds were screened for their antimicrobial activities against two gram positive bacteria, two‐gram negative bacteria, and two fungal strains.

中文翻译：

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硫代二氢嘧啶衍生物的合成及体外抗菌研究

在本研究中，使用双金属TUD-1催化剂由不同的取代芳族醛，乙酰乙酸乙酯和尿素/硫脲合成了一系列硫代二氢嘧啶衍生物。所有合成化合物的结构均通过熔点测定，薄层色谱（TLC），红外（IR），¹ HNMR和¹³ C-NMR值进行表征。筛选所有合成的化合物对两种革兰氏阳性细菌，两种革兰氏阴性细菌和两种真菌菌株的抗菌活性。