Regeneration is a remarkable phenomenon that has been the subject of awe and bafflement for hundreds of years. Although regeneration competence is found in highly divergent organisms throughout the animal kingdom, recent advances in tools used for molecular and genomic characterization have uncovered common genes, molecular mechanisms, and genomic features in regenerating animals. In this review we focus on what is known about how genome regulation modulates cellular potency during regeneration. We discuss this regulation in the context of complex tissue regeneration in animals, from Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate. We emphasize the importance of a detailed molecular understanding of both the mechanisms that regulate genomic output and the functional assays that assess the biological relevance of such molecular characterizations.

中文翻译：

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再生中基因组输出和（Pluri）效能的调节。

再生是一种令人敬畏和困惑的现象，已经有数百年历史了。尽管在整个动物界的高度分化的生物中都发现了再生能力，但是用于分子和基因组表征的工具的最新进展却揭示了再生动物中的常见基因，分子机制和基因组特征。在这篇综述中，我们集中于有关基因组调控如何在再生过程中调节细胞效能的知识。我们在适当的情况下，参照多能性的离体培养细胞模型，在从九头蛇到人类的动物中复杂组织再生的背景下讨论这种调节。