当前位置: X-MOL 学术Chin. J. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
NHC‐catalyzed Redox‐Neutral Aza‐Benzoin Reaction of Aldehydes with Tetrahydroisoquinolines
Chinese Journal of Chemistry ( IF 5.4 ) Pub Date : 2019-12-24 , DOI: 10.1002/cjoc.201900405
Di Jiang 1 , Zijun Wu 1 , Jian Wang 1
Affiliation  

Tetrahydroisoquinoline derivatives are useful synthetic intermediates, which play an important role in the preparation of natural products, pharmaceuticals and other materials. Herein, we report an unprecedented redox‐neutral aza‐benzoin protocol to construct such scaffold. Upon exposure of tetrahydroisoquinolines to aromatic aldehydes in the presence of an NHC catalyst, the C‐1 acylated tetrahydroisoquinolines were obtained in moderate to good yields.

中文翻译:

NHC催化的醛与四氢异喹啉的氧化还原-中性氮杂-苯甲酰反应

四氢异喹啉衍生物是有用的合成中间体,在天然产物,药物和其他材料的制备中起重要作用。在此,我们报道了前所未有的氧化还原中性氮杂安息香方案来构建这种支架。在NHC催化剂存在下将四氢异喹啉暴露于芳族醛中后,以中等至良好的产率获得了C-1酰化的四氢异喹啉。
更新日期:2019-12-25
down
wechat
bug