Traumatic brain injury (TBI) is a major health problem with high rates of mortality and morbidity worldwide. The response of the brain to TBI is orchestrated by a number of cytokines, including interleukin-6 (IL-6). IL-6 is a major cytokine in the central nervous system and it is produced by different cells, such as neurons, glial cells, and endothelial cells. Since glial cells are one of the most important sources and targets of IL-6, we have examined the role of microglia-derived IL-6 in normal conditions and following a model of TBI, cryolesion of the somatosensorial cortex. To this end, tamoxifen-inducible microglial IL-6-deficient (Il6ΔMic , using Cx3cr1 CreER model) mice and control (Il6lox/lox ) mice were used. In normal conditions, microglial IL-6 deficiency reduced deambulation and exploratory behavior and decreased anxiety in a sex-dependent manner. The transcriptome profile following cryolesion was dramatically altered 1 day post-lesion in Il6ΔMic compared with Il6lox/lox mice. However, the phenotype of Il6ΔMic mice was less compromised in the following days, suggesting that compensatory mechanisms are at play.

中文翻译：

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小胶质细胞源性白介素6影响脑外伤后大脑的行为和炎症反应。

颅脑外伤（TBI）是主要的健康问题，在世界范围内死亡率和发病率很高。大脑对TBI的反应是由包括白介素6（IL-6）在内的许多细胞因子共同调控的。IL-6是中枢神经系统中的主要细胞因子，由不同的细胞（例如神经元，神经胶质细胞和内皮细胞）产生。由于神经胶质细胞是IL-6的最重要来源和靶标之一，因此我们在正常情况下并遵循TBI模型（体感皮层的冷冻）检查了小胶质细胞来源的IL-6的作用。为此，使用了他莫昔芬诱导的小胶质细胞IL-6缺陷型（Il6ΔMic，使用Cx3cr1 CreER模型）小鼠和对照（Il6lox / lox）小鼠。在正常情况下 小胶质细胞IL-6缺乏以性别依赖性方式减少了脱氨和探索行为，并减少了焦虑。与Il6lox / lox小鼠相比，Il6ΔMic损伤后第1天，冷冻后的转录组图谱发生了显着变化。但是，II6ΔMic小鼠的表型在接下来的几天受到的损害较小，这表明补偿机制正在发挥作用。