Parkinson's disease (PD) is the most common movement disorder among adults, affecting 2% of the world population older than 65 years of age. No diagnostic biomarker for routine use in clinical settings currently exists. Dysregulation of microRNAs (miRNAs) has been implicated in various neurodegenerative conditions, including PD. Distinct miRNAs have been demonstrated to be involved in the regulation of α‐synuclein, a key player in PD pathogenesis; miR‐153 and miR‐223 are downregulated in the brain and serum of parkinsonian GFAP.HMOX1 transgenic mice where they directly regulate α‐synuclein.

中文翻译：

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唾液 microR-153 和 microR-223 水平作为特发性帕金森病的潜在诊断生物标志物

帕金森病 (PD) 是成年人中最常见的运动障碍，影响全球 2% 的 65 岁以上人口。目前不存在临床环境中常规使用的诊断生物标志物。microRNAs (miRNAs) 的失调与包括 PD 在内的各种神经退行性疾病有关。已证明不同的 miRNA 参与调节 α-突触核蛋白，这是 PD 发病机制的关键参与者；miR-153 和 miR-223 在帕金森病 GFAP.HMOX1 转基因小鼠的大脑和血清中下调，它们直接调节 α-突触核蛋白。