Hypertension has become the leading risk factor for worldwide cardiovascular diseases. Conventional pharmacological treatment, after both dietary and lifestyle changes, is generally proposed. In this review, we present the antihypertensive properties of phytocomplexes from thirteen plants, long ago widely employed in ethnomedicines and, in recent years, increasingly evaluated for their activity in vitro and in vivo, also in humans, in comparison with synthetic drugs acting on the same systems. Here, we focus on the demonstrated or proposed mechanisms of action of such phytocomplexes and of their constituents proven to exert cardiovascular effects. Almost seventy phytochemicals are described and scientifically sound pertinent literature, published up to now, is summarized. The review emphasizes the therapeutic potential of these natural substances in the treatment of the 'high normal blood pressure' or 'stage 1 hypertension', so-named according to the most recent European and U.S. guidelines, and as a supplementation in more advanced stages of hypertension, however needing further validation by clinical trial intensification.

中文翻译：

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经证实有效且用途广泛的抗高血压植物复合物：作用方式和活性成分的个体特征

高血压已成为全球心血管疾病的主要危险因素。通常建议在饮食和生活方式改变后进行常规药物治疗。在这篇综述中，我们介绍了来自 13 种植物的植物复合物的抗高血压特性，这些植物复合物很久以前广泛用于民族医学，近年来，与作用于人体的合成药物相比，它们在体外和体内的活性越来越受到评估。相同的系统。在这里，我们专注于已证明或提议的此类植物复合物及其成分的作用机制，这些成分已被证明可发挥心血管作用。描述了近七十种植物化学物质，并总结了迄今为止出版的科学合理的相关文献。