A simple and efficient synthetic route to various 1,4-disubstituted tetrahydro-β-carbolines and tetrahydropyrano[3,4-b]indoles in high yields and stereoselectivity via LiClO4-catalyzed SN2-type ring opening of aziridines and epoxides with indoles followed by p-toluenesulfonic acid (PTSA) catalyzed Pictet-Spengler reaction is described.

中文翻译：

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通过氮丙啶和环氧化物与吲哚/醛的开环/ Pictet-Spengler反应合成1,4-二取代的四氢-β-咔啉和四氢吡喃并吲哚的合成路线。

一种简单有效的合成路线，可通过LiClO4催化的氮丙啶和环氧化物的SN2型开环与吲哚，然后是吲哚，高产率和立体选择性地合成各种1,4-二取代的四氢-β-咔啉和四氢吡喃并[3,4-b]吲哚描述了对甲苯磺酸（PTSA）催化的Pictet-Spengler反应。