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C-lection by the DM15 Motif Gets LARP1 to the TOP.
Structure ( IF 5.7 ) Pub Date : 2019-12-03 , DOI: 10.1016/j.str.2019.11.010
Mark A Bayfield 1 , Kyra Kerkhofs 1 , Farnaz Mansouri-Noori 1
Affiliation  

LARP1 proteins integrate the translation and stability of 5'TOP mRNAs with signaling from the mTOR pathway, but the mechanism is not well understood. In this issue of Structure, Cassidy et al. (2019) propose that the LARP1-DM15 motif modulates access to the 5'TOP mRNA's m7G-ppp-Cytosine cap.

中文翻译:

DM15母题进行的C形选举将LARP1推到顶部。

LARP1蛋白整合了5'TOP mRNA的翻译和稳定性以及来自mTOR途径的信号传导,但其机理尚不清楚。在本期《结构》中,Cassidy等人。(2019)提出LARP1-DM15基序可调节对5'TOP mRNA的m7G-ppp-Cytosine帽的访问。
更新日期:2019-12-04
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