Innate behaviors involve both reflexive motor programs and enduring internal states, but how these responses are coordinated by the brain is not clear. In Drosophila, male-specific P1 interneurons promote courtship song, as well as a persistent internal state that prolongs courtship and enhances aggressiveness. However, P1 neurons themselves are not persistently active. Here, we identify pCd neurons as persistently active, indirect P1 targets that are required for P1-evoked persistent courtship and aggression. Acute activation of pCd neurons alone is inefficacious but enhances and prolongs courtship or aggression promoted by female cues. Brief female exposure induces a persistent increase in male aggressiveness, an effect abrogated by interruption of pCd activity. pCd activity is not sufficient but necessary for persistent physiological activity, implying an essential role in a persistence network. Thus, P1 neurons coordinate both command-like control of courtship song and a persistent internal state of social arousal mediated by pCd neurons.

中文翻译：

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在集成器中起作用以促进果蝇持续行为状态的神经元。

先天行为涉及反射性运动程序和持久的内部状态，但大脑如何协调这些反应尚不清楚。在果蝇中，雄性特异性 P1 中间神经元促进求爱歌曲，以及延长求爱和增强攻击性的持久内部状态。然而，P1 神经元本身并不是持续活跃的。在这里，我们将 pCd 神经元识别为 P1 诱发的持续求爱和攻击所需的持续活跃的间接 P1 目标。单独急性激活 pCd 神经元是无效的，但会增强和延长由女性线索促进的求爱或攻击性。短暂的女性暴露会导致男性攻击性持续增加，这种影响会因 pCd 活性的中断而消失。pCd 活性对于持续的生理活动是不够的，但却是必需的，暗示在持久性网络中的重要作用。因此，P1 神经元协调求爱歌曲的命令式控制和由 pCd 神经元介导的持续的内部社会唤醒状态。