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Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.
Bioscience, Biotechnology, and Biochemistry ( IF 1.6 ) Pub Date : 2019-08-29 , DOI: 10.1080/09168451.2019.1659714
Sayaka Shinji 1 , Shunichi Nakamura 1 , Yuma Nihashi 2 , Koji Umezawa 3 , Tomohide Takaya 1, 2, 3
Affiliation  

A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma (RMS), which is the most frequent soft tissue tumor in children. The present study examined the anti-tumor effects of berberine and palmatine on expansions of three human embryonal RMS cell lines; ERMS1, KYM1, and RD. Intracellular incorporation of berberine was relatively higher than that of palmatine in every RMS cell line. Berberine significantly inhibited the cell cycle of all RMS cells at G1 phase. On the other hand, palmatine only suppressed the growth of RD cells. Both of berberine and palmatine strongly inhibited the growth of tumorsphere of RD cells in three-dimensional culture. These results indicate that berberine derivatives have the potential of anti-tumor drugs for RMS therapy.Abbreviations: ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; RMS: rhabdomyosarcoma.

中文翻译:

小ber碱和棕榈碱抑制人横纹肌肉瘤细胞的生长。

已知一种天然的异喹啉生物碱小ber碱通过诱导细胞周期停滞在各种癌细胞中表现出抗肿瘤活性。然而,尚未研究小碱及其类似物是否抑制横纹肌肉瘤(RMS)的生长,横纹肌肉瘤是儿童中最常见的软组织肿瘤。本研究检查了小ber碱和棕榈碱对三种人类胚胎RMS细胞系扩增的抗肿瘤作用;ERMS1,KYM1和RD。在每个RMS细胞系中,小ber碱的细胞内掺入相对高于棕榈碱。小ber碱显着抑制了所有RMS细胞在G1期的细胞周期。另一方面,棕榈碱仅抑制RD细胞的生长。小three碱和棕榈碱在三维培养中均强烈抑制RD细胞肿瘤球的生长。这些结果表明,小ber碱衍生物具有用于RMS治疗的抗肿瘤药物的潜力。ERMS:胚胎横纹肌肉瘤;RMS:横纹肌肉瘤。
更新日期:2019-12-04
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