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Significant group-level hotspots found in deep brain regions during transcranial direct current stimulation (tDCS): A computational analysis of electric fields
Clinical Neurophysiology ( IF 4.7 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.clinph.2019.11.018
Jose Gomez-Tames 1 , Akihiro Asai 1 , Akimasa Hirata 2
Affiliation  

OBJECTIVE Transcranial direct current stimulation (tDCS) is a neuromodulation scheme that delivers a small current via electrodes placed on the scalp. The target is generally assumed to be under the electrode, but deep brain regions could also be involved due to the large current spread between the electrodes. This study aims to computationally evaluate if group-level hotspots exist in deep brain regions for different electrode montages. METHODS We computed the tDCS-generated electric fields (EFs) in a group of subjects using interindividual registration methods that permitted the projection of EFs from individual realistic head models (n = 18) to a standard deep brain region. RESULTS The spatial distribution and peak values (standard deviation of 14%) of EFs varied significantly. Nevertheless, group-level EF hotspots appeared in deep brain regions. The caudate had the highest field peaks in particular for F3-F4 montage (70% of maximum cortical EF), while other regions reach field peaks of 50%. CONCLUSIONS tDCS at deeper regions may include not only modulation via underlying cortical or subcortical circuits but also modulation of deep brain regions. SIGNIFICANCE The presented EF atlas in deep brain regions can be used to explain tDCS mechanism or select the most appropriate tDCS montage.

中文翻译:

在经颅直流电刺激 (tDCS) 期间在大脑深部区域发现的显着组级热点:电场的计算分析

目的 经颅直流电刺激 (tDCS) 是一种神经调节方案,通过放置在头皮上的电极提供小电流。通常假设目标位于电极下方,但由于电极之间的大电流传播,也可能涉及深部大脑区域。本研究旨在通过计算评估不同电极蒙太奇的大脑深部区域是否存在组级热点。方法我们使用个体间配准方法计算了一组受试者中 tDCS 生成的电场 (EF),该方法允许将 EF 从单个真实头部模型 (n = 18) 投影到标准的大脑深部区域。结果 EFs的空间分布和峰值(标准偏差为14%)变化很大。尽管如此,组级 EF 热点出现在大脑深部区域。尾状核具有最高的场峰,尤其是 F3-F4 蒙太奇(最大皮层 EF 的 70%),而其他区域则达到 50% 的场峰。结论 较深区域的 tDCS 可能不仅包括通过底层皮层或皮层下回路的调制,还包括对深部大脑区域的调制。意义 深部脑区的 EF 图谱可用于解释 tDCS 机制或选择最合适的 tDCS 蒙太奇。
更新日期:2020-03-01
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