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Rebuttal to editorial: Sodium retention by uPA in nephrotic syndrome?
Acta Physiologica ( IF 6.3 ) Pub Date : 2019-12-03 , DOI: 10.1111/apha.13427
Bernhard N Bohnert 1, 2, 3 , Sandip Kanse 4 , Silke Haerteis 5 , Christoph Korbmacher 6 , Ferruh Artunc 1, 2, 3
Affiliation  

We welcome the opportunity to reply to the elegant editorial of Prof. Ehmke 1 in which he highlights contradicting conclusions reached by Hinrichs et al. 2 and by us 3 in two recently published articles in Acta Physiologica. In our reply, we first comment on some technical aspects discussed by Prof. Ehmke as possible explanations for the discrepant conclusions reached in the two studies. In addition, we highlight some in vivo data reported by Hinrichs et al. 2 which in our view do not oppose but rather support our conclusion that urokinase, also known as urokinase‐type plasminogen activator (uPA), is not essential for sodium retention in nephrotic syndrome.

中文翻译:

反驳社论:uPA在肾病综合征中保留钠?

我们欢迎有机会对Ehmke 1教授的优雅社论做出回应,他在讲话中强调了Hinrichs等人得出的矛盾结论。2和我们3中最近在Acta Physiologica中发表的两篇文章。在我们的答复中,我们首先对Ehmke教授所讨论的一些技术方面进行评论,以作为对这两项研究得出的不同结论的可能解释。此外,我们重点介绍了Hinrichs等人报道的一些体内数据。2我们认为并不反对,而是支持我们的结论,即尿激酶,也称为尿激酶型纤溶酶原激活剂(uPA),对于肾病综合征中的钠retention留不是必不可少的。
更新日期:2019-12-03
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