Comprising a hydrogen bond crosslinked agarose (Aga) network and a covalently crosslinked hydroxyethyl polyacrylate network, a simple, easily controlled one‐pot construction of agarose/hydroxyethyl polyacrylate (Aga/PHEA) double network (DN) elastomer hydrogel is developed. The Aga/PHEA DN gels combining the strengths of both hydrogel and elastomer indicate excellent fatigue resistance, toughness together with rapid, high recoverable rate. The compression strength, tensile strength, and toughness of DN gels can reach 41 MPa, 1.0 MPa, and 6.7 MJ m⁻³. Due to the thermoreversible feature of agarose, the gel displays an excellent recoverable ability with the elastic modulus recovery of 93% and the energy loss recovery of 90%, respectively, after heating the compressed and released gels. Interestingly, the gels indicate a typical rubber behavior with a small and almost overlapped hysteresis loop and excellent fatigue resistance by simply regulating the content of the second network HEA. Besides, the in vitro MTT and cell adhesion tests confirm the good biological compatibility of the gels. The active hydroxyl groups in the gel can be bonded with functionalized molecule for different needs. The studies reveal that the DN elastomer hydrogels with excellent mechanical properties, biocompatibility, and functionalization will significantly provide a new road to gel researches and applications.

中文翻译：

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热可逆结构上可恢复的双网络弹性体水凝胶

由氢键交联的琼脂糖（Aga）网络和共价交联的丙烯酸羟乙基酯网络组成，开发了一种简单易控制的琼脂糖/丙烯酸羟乙酯（Aga / PHEA）双网络（DN）弹性体水凝胶的单罐结构。Aga / PHEA DN凝胶结合了水凝胶和弹性体的强度，显示出优异的抗疲劳性，韧性以及快速，高回收率。DN凝胶的压缩强度，拉伸强度和韧性可以达到41 MPa，1.0 MPa和6.7 MJ m ^-3。由于琼脂糖具有热可逆性，在加热压缩和释放的凝胶后，凝胶显示出出色的可恢复能力，弹性模量恢复分别为93％和能量损失恢复为90％。有趣的是，这些凝胶通过简单地调节第二网络HEA的含量即可显示出典型的橡胶行为，具有小的且几乎重叠的磁滞回线和出色的抗疲劳性。此外，体外MTT和细胞粘附试验证实了凝胶的良好生物相容性。凝胶中的活性羟基可与功能化分子结合，以满足不同需求。研究表明，具有出色的机械性能，生物相容性和功能性的DN弹性体水凝胶将为凝胶的研究和应用提供新的途径。