Implanted pacemakers are usually bulky and rigid electronics that are constraint by limited battery lifetimes, and need to be installed and repaired via surgeries that risk secondary infection and injury. In this work, a flexible self-powered photoelectric cardiac stimulator is demonstrated based on hydrogenated amorphous Si (a-Si:H) radial p-i-n junctions (RJs), constructed upon standing Si nanowires grown directly on aluminum thin foils. The flexible RJ stimulators, with an open-circuit voltage of 0.67 V and short-circuit current density of 12.7 mA cm-2 under standard AM1.5G illumination, can be conformally attached to the uneven tissue surface to pace heart-beating under modulated 650 nm laser illumination. In vivo pacing evaluations on porcine hearts show that the heart rate can be effectively controlled by the external photoelectric stimulations, to increase from the normal rate of 101-128 beating min-1 . Importantly, the a-Si:H RJ units are highly biofriendly and biodegradable, with tunable lifetimes in phosphate-buffered saline environment controlled by surface coating and passivation, catering to the needs of short term or lasting cardiac pacing applications. This implantable a-Si:H RJ photoelectric stimulation strategy has the potential to establish eventually a self-powered, biocompatible, and conformable cardiac pacing technology for clinical therapy.

中文翻译：

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通过柔性和可降解的非晶硅径向结刺激器进行光电心脏起搏。

植入式起搏器通常是笨重的刚性电子设备，受电池寿命有限的限制，需要通过手术进行安装和维修，否则可能会造成继发感染和伤害。在这项工作中，展示了一种基于氢化非晶Si（a-Si：H）径向销结（RJ）的柔性自供电光电心脏刺激器，该销钉结基于直接在铝薄箔上生长的直立式硅纳米线构建而成。灵活的RJ刺激器，在标准AM1.5G照明下的开路电压为0.67 V，短路电流密度为12.7 mA cm-2，可以共形地附着在不平坦的组织表面上，以在调制后的650下加快心跳nm激光照明。对猪心脏的体内起搏评估表明，可以通过外部光电刺激有效控制心率，使其比正常的心律跳动min-1更高，为101-128。重要的是，a-Si：H RJ装置具有高度的生物友好性和可生物降解性，在磷酸盐缓冲盐水环境中，通过表面涂层和钝化来控制其使用寿命，可满足短期或长期心脏起搏应用的需求。这种可植入的a-Si：H RJ光电刺激策略有可能最终建立一种用于临床治疗的自供电，生物相容性和顺应性的心脏起搏技术。通过表面涂层和钝化控制，在磷酸盐缓冲盐水环境中具有可调节的使用寿命，可满足短期或持久性心脏起搏应用的需求。这种可植入的a-Si：H RJ光电刺激策略有可能最终建立一种用于临床治疗的自供电，生物相容性和顺应性的心脏起搏技术。通过表面涂层和钝化控制，在磷酸盐缓冲盐水环境中具有可调节的使用寿命，可满足短期或持久性心脏起搏应用的需求。这种可植入的a-Si：H RJ光电刺激策略有可能最终建立一种用于临床治疗的自供电，生物相容性和顺应性的心脏起搏技术。