Financial toxicity is a broad term to describe the economic consequences and subjective burden resulting from a cancer diagnosis and treatment. As financial toxicity is associated with poor disease outcomes, recognition of this problem and calls for strategies to identify and support those most at risk are increasing. Men with localized prostate cancer face treatment choices including active surveillance, prostatectomy or radiotherapy. The fact that potential patient out-of-pocket costs might influence decision making has rarely been acknowledged and, overall, the risk of financial toxicity for men with localized prostate cancer remains poorly studied. This shortfall requires a work-up in the context of prostate cancer and a multidimensional framework for considering a patient's risk of financial toxicity. The major elements of this framework are direct and indirect costs, patient-specific values, expectations of possible financial burdens, and individual economic circumstances. Current data indicate that total cost patterns probably differ by treatment modality: surgery might have an increased short-term effect, whereas radiotherapy might have an increased long-term risk of financial toxicity. Specific thresholds of patient income levels or out-of-pocket costs that predict risk of financial toxicity are difficult to identify. Compared with other malignancies, prostate cancer might have a lower overall risk of financial toxicity, but persistent post-treatment urinary, bowel or sexual adverse effects are likely to increase this risk.

中文翻译：

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与局部前列腺癌治疗相关的经济毒性。

经济毒性是一个广义的术语，用于描述癌症诊断和治疗导致的经济后果和主观负担。由于经济毒性与不良的疾病结果有关，因此越来越多地认识到这一问题并呼吁制定策略来识别和支持那些最危险的人。患有局限性前列腺癌的男性面临治疗选择，包括主动监测、前列腺切除术或放疗。潜在的患者自付费用可能会影响决策这一事实很少被承认，总体而言，对患有局限性前列腺癌的男性的经济毒性风险的研究仍然很少。这种不足需要在前列腺癌的背景下进行检查，并需要一个多维框架来考虑患者的经济毒性风险。该框架的主要元素是直接和间接成本、特定于患者的价值观、对可能的经济负担的预期以及个人经济情况。目前的数据表明，总成本模式可能因治疗方式而异：手术可能会增加短期效果，而放疗可能会增加长期经济毒性风险。预测财务毒性风险的患者收入水平或自付费用的具体阈值很难确定。与其他恶性肿瘤相比，前列腺癌的总体经济毒性风险可能较低，但治疗后持续的泌尿、肠道或性方面的不良反应可能会增加这种风险。和个人经济情况。目前的数据表明，总成本模式可能因治疗方式而异：手术可能会增加短期效果，而放疗可能会增加长期经济毒性风险。预测财务毒性风险的患者收入水平或自付费用的具体阈值很难确定。与其他恶性肿瘤相比，前列腺癌的总体经济毒性风险可能较低，但治疗后持续的泌尿、肠道或性方面的不良反应可能会增加这种风险。和个人经济情况。目前的数据表明，总成本模式可能因治疗方式而异：手术可能会增加短期效果，而放疗可能会增加长期经济毒性风险。预测财务毒性风险的患者收入水平或自付费用的具体阈值很难确定。与其他恶性肿瘤相比，前列腺癌的总体经济毒性风险可能较低，但治疗后持续的泌尿、肠道或性方面的不良反应可能会增加这种风险。预测财务毒性风险的患者收入水平或自付费用的具体阈值很难确定。与其他恶性肿瘤相比，前列腺癌的总体经济毒性风险可能较低，但治疗后持续的泌尿、肠道或性方面的不良反应可能会增加这种风险。预测财务毒性风险的患者收入水平或自付费用的具体阈值很难确定。与其他恶性肿瘤相比，前列腺癌的总体经济毒性风险可能较低，但治疗后持续的泌尿、肠道或性方面的不良反应可能会增加这种风险。