Resident memory T cells (T_RM cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T_RM cell populations to protective immunity and the factors that govern their localization to different compartments of the lung are not well understood. Here, we show that airway and interstitial T_RM cells have distinct effector functions and that CXCR6 controls the partitioning of T_RM cells within the lung by recruiting CD8 T_RM cells to the airways. The absence of CXCR6 significantly decreases airway CD8 T_RM cells due to altered trafficking of CXCR6^−/− cells within the lung, and not decreased survival in the airways. CXCL16, the ligand for CXCR6, is localized primarily at the respiratory epithelium, and mice lacking CXCL16 also had decreased CD8 T_RM cells in the airways. Finally, blocking CXCL16 inhibited the steady-state maintenance of airway T_RM cells. Thus, the CXCR6/CXCL16 signaling axis controls the localization of T_RM cells to different compartments of the lung and maintains airway T_RM cells.

居民记忆T细胞（T _RM细胞）是抵抗呼吸道病原体的重要一线防御，但是人们对肺T _RM细胞群体对保护性免疫的独特贡献以及控制其定位于肺不同部位的因素的了解却很少。 。在这里，我们表明，气道和间质性Ť _RM细胞具有不同的效应子功能和控制CXCR6 T的分割_RM通过募集CD8 T细胞在肺中_RM细胞向气道。不存在CXCR6的显著降低气道的CD8 T _RM细胞由于CXCR6的改变的贩卖^{- / -}肺内的细胞，并没有降低呼吸道的存活率。CXCL16的配体CXCL16主要位于呼吸道上皮，缺乏CXCL16的小鼠的气道中CD8 T _RM细胞也减少了。最后，阻断CXCL16抑制了气道T _RM细胞的稳态维持。因此，CXCR6 / CXCL16信号轴控制T的定位_RM细胞肺的不同隔室，并保持气道Ť _RM细胞。