Excess bilirubin in the body will lead to serious health problems; however, its efficient removal remains a challenge in the clinical field because the available sorbent materials still suffer from serious performance issues, performance declining in a high-content albumin environment. Herein, we prepared a novel polydopamine (PDA) decorated ordered mesoporous carbon (OMC) material for the efficient removal of bilirubin in albumin-rich conditions. OMC was used as the supporting material due to its high specific surface area and its good affinity to hydrophobic analytes. PDA was then decorated on the OMC material through a facile self-assembly process to form a surface-imprinted layer. The obtained PDA-coated OMC material (OMC@PDA) exhibited excellent adsorption performance towards bilirubin in albumin-free conditions, in which its theoretical maximum adsorption amount was calculated to be 513.54 mg g-1. The imprinted PDA layer, for which the association constant towards bilirubin reached 4.51 × 104 M-1, endowed OMC@PDA with a competitive affinity compared to albumin. Therefore the materials showed good adsorption capacity and efficiency even in an albumin-rich environment (the adsorption equilibrated at 122.7 mg g-1 in 30 min). In addition, the good biocompatibility of OMC@PDA was demonstrated by hemolysis assay and protein fouling evaluation, which indicated the feasibility of applying this material in clinical situations.

中文翻译：

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聚多巴胺修饰的有序介孔碳可在富含白蛋白的条件下有效去除胆红素。

体内胆红素过多会导致严重的健康问题；然而，由于有效的吸附剂材料仍然遭受严重的性能问题，在高含量白蛋白环境中性能下降，因此有效去除其仍然是临床领域的挑战。在这里，我们准备了一种新型的聚多巴胺（PDA）装饰的有序介孔碳（OMC）材料，以在富含白蛋白的条件下有效去除胆红素。由于OMC具有高的比表面积和对疏水性分析物的良好亲和力，因此它被用作支撑材料。然后，通过简便的自组装工艺将PDA装饰在OMC材料上，以形成表面压印层。在无白蛋白的条件下，所得的PDA包覆的OMC材料（OMC @ PDA）对胆红素具有优异的吸附性能，其中理论最大吸附量经计算为513.54 mg g-1。印迹的PDA层对胆红素的缔合常数达到4.51×104 M-1，与白蛋白相比，赋予了OMC @ PDA竞争性的亲和力。因此，即使在富含白蛋白的环境中，该材料也显示出良好的吸附能力和效率（在30分钟内吸附达到122.7 mg g-1的平衡）。此外，通过溶血分析和蛋白质污染评估证明了OMC @ PDA的良好生物相容性，表明该材料在临床中的可行性。因此，即使在富含白蛋白的环境中，该材料也显示出良好的吸附能力和效率（在30分钟内吸附达到122.7 mg g-1的平衡）。此外，通过溶血分析和蛋白质污染评估证明了OMC @ PDA的良好生物相容性，表明该材料在临床中的可行性。因此，即使在富含白蛋白的环境中，该材料也显示出良好的吸附能力和效率（在30分钟内吸附达到122.7 mg g-1的平衡）。此外，通过溶血分析和蛋白质污染评估证明了OMC @ PDA的良好生物相容性，表明该材料在临床中的可行性。