The preparation of fluorine-containing compounds has attracted considerable attention due to the important applications of their related chemicals. Among the candidates, trifluoroacetimidoyl halides are considered as potent trifluoromethyl synthons to construct a wide variety of trifluoromethyl-containing compounds and trifluoromethyl-substituted N-heterocycles, which have found extensive applications in the fields of organic synthesis, pharmaceuticals, agrochemicals, and materials science. In the review, recent advances in the synthetic applications of trifluoroacetimidoyl halides are summarized. We specially focused on two different reaction modes upon trifluoroacetimidoyl halides, namely, coupling and annulation reactions to illustrate their synthetic applications and potentials in the construction of valuable trifluoromethyl-containing molecules. Their preparations were covered as well.

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三氟乙酰亚胺基卤化物：有力的合成来源

含氟化合物的制备由于其相关化学物质的重要应用而备受关注。在候选物中，三氟乙酰亚胺基卤化物被认为是有效的三氟甲基合成子，可构建各种含三氟甲基的化合物和三氟甲基取代的N-杂环，这些化合物已在有机合成，药物，农用化学品和材料科学领域得到了广泛的应用。在综述中，总结了三氟乙酰亚胺基卤化物的合成应用的最新进展。我们特别关注于三氟乙酰亚胺基卤化物的两种不同反应模式，即 偶联和环化反应，以说明其在有价值的含三氟甲基分子构建中的合成应用和潜力。他们的准备也包括在内。