Simian foamy viruses (SFVs) are complex retroviruses that are widespread throughout nonhuman primates. SFVs can also be transmitted to humans, mostly through bites. We previously observed that primary zoonotic gorilla SFV strains grow much more slowly than laboratory-adapted chimpanzee strains. Here, we tested the hypothesis that the growth of SFV is limited by interferon (IFN) using inhibitors of cellular pathways involved in the induction or action of type I IFN. Inhibitors of JAK1/2 (Ruxolitinib) and TBK-1 (BX795) led to a 2- to 4-fold higher percentage of cells infected with zoonotic gorilla SFVs but did not affect the replication of laboratory-adapted chimpanzee SFVs. IKK2 inhibitors (TPCA-1 and BMS345541) had no effect on any of the SFV strains. In conclusion, the addition of molecules that inhibit the type I IFN response to the culture medium can be used as a simple and efficient method to enhance the replication of zoonotic gorilla SFVs.

中文翻译：

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干扰素反应的抑制剂增加了大猩猩猿泡沫病毒的复制。

猿猴泡沫病毒 (SFV) 是复杂的逆转录病毒，广泛存在于非人类灵长类动物中。SFV 也可以传播给人类，主要是通过叮咬。我们之前观察到，原代人畜共患大猩猩 SFV 菌株的生长速度比实验室适应的黑猩猩菌株慢得多。在这里，我们使用参与 I 型干扰素诱导或作用的细胞通路抑制剂测试了 SFV 的生长受干扰素 (IFN) 限制的假设。JAK1/2 (Ruxolitinib) 和 TBK-1 (BX795) 的抑制剂导致感染人畜共患大猩猩 SFV 的细胞百分比高出 2 到 4 倍，但不影响实验室适应的黑猩猩 SFV 的复制。IKK2 抑制剂（TPCA-1 和 BMS345541）对任何 SFV 菌株都没有影响。综上所述，