BACKGROUND The study of heritable epigenetic changes in arsenic exposure has intensified over the last decade. Groundwater arsenic contamination causes a great threat to humans and, to date, no accurate measure has been formulated for remediation. The fascinating possibilities of epi-therapeutics identify the need for an in-depth mechanistic understanding of the epigenetic landscape. OBJECTIVE In this comprehensive review, we have set to analyze major studies pertaining to histone post-translational modifications in arsenic-mediated disease development and carcinogenesis during last ten years (2008-2018). RESULTS The role of the specific histone marks in arsenic toxicity has been detailed. A comprehensive list that includes major arsenic-induced histone modifications identified for the last 10 years has been documented and details of different states of arsenic, organisms, exposure type, study platform, and findings were provided. An arsenic signature panel was suggested to help in early prognosis. An attempt has been made to identify the grey areas of research. PROSPECTS Future prospective multi-target analyses of the inter-molecular crosstalk among different histone marks are needed to be explored further in order to understand the mechanism of arsenic toxicity and carcinogenicity and to confirm the suitability of these epi-marks as prognostic markers.

中文翻译：

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了解砷暴露的机理见解并解码组蛋白密码。

背景技术在过去十年中，关于砷暴露的可遗传表观遗传学变化的研究已经加强。地下水砷污染对人类造成了巨大威胁，迄今为止，尚未制定出准确的补救措施。表观疗法的引人入胜的可能性表明需要对表观遗传学景观进行深入的机械理解。目的在这项全面的综述中，我们将着手分析与过去十年（2008-2018年）中砷介导的疾病发展和致癌作用中的组蛋白翻译后修饰有关的主要研究。结果已详细说明了特定组蛋白标记在砷毒性中的作用。已记录了一个完整的清单，其中包括在过去十年中发现的主要砷诱导的组蛋白修饰，并提供了不同状态的砷，生物，暴露类型，研究平台和发现的详细信息。建议使用砷签名小组以帮助早期预后。已经尝试确定研究的灰色领域。前景有待进一步探讨不同组蛋白标记之间分子间串扰的未来前瞻性多靶点分析，以了解砷毒性和致癌性的机制，并确认这些Epi标记作为预后标记的适用性。已经尝试确定研究的灰色领域。前景有待进一步探讨不同组蛋白标记之间分子间串扰的未来前瞻性多靶点分析，以了解砷毒性和致癌性的机制，并确认这些Epi标记作为预后标记的适用性。已尝试确定研究的灰色领域。前景有待进一步探讨不同组蛋白标记之间分子间串扰的未来前瞻性多靶点分析，以了解砷毒性和致癌性的机制，并确认这些Epi标记作为预后标记的适用性。