Humoral immunity critically depends on appropriate B cell responses. B cell activation, proliferation, differentiation and antibody secretion are processes carefully orchestrated by a complex network of intracellular signaling pathways and transcription factors. In order to meet the energetic and biosynthetic demands of protein synthesis and cell division, signal transduction pathways reshape the metabolic profile of activated B cells. However, the relationship between signaling and metabolism is by no means unidirectional. Emerging evidence suggests that shifts in available fuel sources and intracellular metabolite concentrations profoundly impact cell fate decisions. The reciprocal regulation of cell signaling and metabolism could potentially be exploited to curb immune dysfunction in metabolic disorders or to antagonize autoimmunity and B cell malignancies.

中文翻译：

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B细胞免疫反应的代谢控制。

体液免疫关键取决于适当的B细胞反应。B细胞的激活，增殖，分化和抗体分泌是由细胞内信号传导途径和转录因子的复杂网络精心策划的过程。为了满足蛋白质合成和细胞分裂的能量和生物合成需求，信号转导途径重塑了活化B细胞的代谢特性。但是，信号转导与代谢之间的关系绝不是单向的。越来越多的证据表明，可用燃料源和细胞内代谢物浓度的变化会深刻影响细胞命运的决定。