BACKGROUND There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little is known about the impact of obesity on epigenetic aging of metabolically active visceral adipose tissue (VAT). Herein, we aimed to test whether obesity accelerates VAT epigenetic aging in subjects with severe obesity. RESULTS A significant and positive correlation between chronological age and epigenetic age, estimated with a reduced version of the Horvath's epigenetic clock, was found in both blood (r = 0.78, p = 9.4 × 10-12) and VAT (r = 0.80, p = 1.1 × 10-12). Epigenetic age acceleration, defined as the residual resulting from regressing epigenetic age on chronological age, was significantly correlated with body mass index (BMI) in VAT (r = 0.29, p = 0.037). Multivariate linear regression analysis showed that, after adjusting for chronological age, sex and metabolic syndrome status, BMI remained significantly associated with epigenetic age acceleration in VAT (beta = 0.15, p = 0.035), equivalent to 2.3 years for each 10 BMI units. Binomial logistic regression showed that BMI-adjusted epigenetic age acceleration in VAT was significantly associated with a higher loss of excess body weight following biliopancreatic diversion with duodenal switch surgery (odds ratio = 1.21; 95% CI = 1.04-1.48; p = 0.03). CONCLUSIONS Epigenetic age acceleration increases with BMI in VAT, but not in blood, as previously reported in liver. These results suggest that obesity is associated with epigenetic age acceleration of metabolically active tissues. Further studies that deepen the physiological relevance of VAT epigenetic aging will help to better understand the onset of metabolic syndrome and weight loss dynamics following bariatric surgery.

中文翻译：

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体重指数与严重肥胖患者内脏脂肪组织的表观遗传年龄增长有关。

背景技术有确凿的证据表明，肥胖症会加速肝脏表观遗传衰老。但是，与容易获得的血液或皮下脂肪组织不同，肥胖对代谢活性内脏脂肪组织（VAT）的表观遗传衰老的影响知之甚少。在本文中，我们旨在测试肥胖症是否能促进严重肥胖症患者的增值税表观遗传衰老。结果在血液（r = 0.78，p = 9.4×10-12）和增值税（r = 0.80，p = 1.1×10-12）。表观遗传年龄加速，定义为表观遗传年龄按时间顺序回归的残差，与增值税中的体重指数（BMI）显着相关（r = 0.29，p = 0.037）。多元线性回归分析显示，在按年龄，性别和代谢综合征状态进行调整后，BMI仍然与表观遗传加速的增值税显着相关（β= 0.15，p = 0.035），相当于每10个BMI单位2.3年。二项式逻辑回归显示，经十二指肠开关手术切除胆胰后，BMI调整的表观遗传年龄加速与超重的较高损失显着相关（优势比= 1.21; 95％CI = 1.04-1.48; p = 0.03）。结论先前报道在肝脏中，表观遗传年龄的加速随着BMI的增加而增加，但不随血液的增加而增加。这些结果表明，肥胖与代谢活性组织的表观遗传年龄的增长有关。