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Analysis of reporting completeness in exercise cancer trials: a systematic review.
BMC Medical Research Methodology ( IF 4 ) Pub Date : 2019-12-02 , DOI: 10.1186/s12874-019-0871-0
Jose Francisco Meneses-Echavez 1, 2 , Indira Rodriguez-Prieto 3 , Mark Elkins 4 , Javier Martínez-Torres 5 , Lien Nguyen 1 , Julia Bidonde 1, 6
Affiliation  

BACKGROUND Exercise is an effective therapeutic intervention for cancer survivors. Concerns about the completeness of reporting of exercise interventions have been raised in the literature, but without any formal analysis. This study aimed to evaluate the completeness of reporting of exercise interventions for cancer survivors in a large sample of randomized clinical trials (RCTs). METHODS We developed a pre-defined protocol. We searched MEDLINE, EMBASE, and CENTRAL for exercise trials in oncology between 2010 and 2017. Pairs of independent researchers screened the records, extracted study characteristics, and assessed 16 items on the TIDieR checklist (i.e., the 12 items, with item 5 divided into two and item 8 divided into four). For each of these items, the percentage of interventions in the included studies that reported the item was calculated. RESULTS We included 131 RCTs reporting 138 interventions in the analysis. Breast cancer was the most common type of cancer (69, 50%), and aerobic exercise was the most studied exercise modality (43, 30%) followed by combined aerobic and resistance training (40, 28%). Completeness of reporting ranged from 42 to 96% among the TIDieR items; none of the items was fully reported. 'Intervention length' was the most reported item across interventions (133, 96%), followed by 'rationale' (131, 95%), whereas 'provider' (58, 42%) and 'how well (planned)' (63, 46%) were the two least reported items. Half of the TIDieR items were completely reported in 50 to 70% of the interventions, and only four items were reported in more than 80% of the interventions (Items 2 and 8a to c). The seven items deemed to be core for replication (Items 3 to 9) exhibited a mean reporting of 71%, ranging from 42 to 96%. CONCLUSION Exercise training interventions for cancer survivors are incompletely reported across RCTs published between 2010 and 2017. The reporting of information about the provider, materials, and modifications require urgent improvements. Stronger reporting will enhance usability of trial reports by both healthcare providers and survivors, and will help to reduce research waste.

中文翻译:

运动癌症试验中报告完整性的分析:系统评价。

背景技术运动是对癌症幸存者的有效治疗干预。关于运动干预报告的完整性的担忧已经在文献中提出,但是没有任何正式的分析。这项研究旨在评估大量随机临床试验(RCT)中癌症幸存者运动干预报告的完整性。方法我们开发了一个预定义的协议。我们搜索了MEDLINE,EMBASE和CENTRAL在2010年至2017年之间进行的肿瘤学运动试验。成对的独立研究人员筛选了记录,提取了研究特征,并评估了TIDieR清单上的16项(即12项,其中5项分为两个,第8项分成四个)。对于这些项目,计算了报告该项目的纳入研究的干预百分比。结果我们纳入了131个RCT,报告了138项干预措施。乳腺癌是最常见的癌症类型(69%,50%),有氧运动是研究最多的运动方式(43%,30%),其次是有氧和阻力训练相结合(40%,28%)。在TIDieR项目中,报告的完整性为42%至96%;没有项目被完全报告。“干预时间”是所有干预措施中报告最多的项目(133,96%),其次是“理性”(131,95%),而“提供者”(58,42%)和“做得好(计划)”(63) (46%)是报告最少的两个项目。在50%至70%的干预措施中,有一半的TIDieR项目已完全报告,超过80%的干预措施仅报告了4个项目(项目2和8a至c)。被认为是复制核心的七个项目(项目3至9)的平均报告率为71%,范围从42%至96%。结论在2010年至2017年间发布的所有RCT中,针对癌症幸存者的运动训练干预措施均不完整。关于提供者,材料和修改的信息的报告需要紧急改进。更强大的报告功能将增强医疗保健提供者和幸存者的试验报告的可用性,并有助于减少研究浪费。结论在2010年至2017年间发布的所有RCT中,针对癌症幸存者的运动训练干预措施均不完整。关于提供者,材料和修改的信息的报告需要紧急改进。更强大的报告功能将增强医疗保健提供者和幸存者的试验报告的可用性,并有助于减少研究浪费。结论在2010年至2017年间发布的所有RCT中,针对癌症幸存者的运动训练干预措施均不完整。关于提供者,材料和修改的信息的报告需要紧急改进。更强大的报告功能将增强医疗保健提供者和幸存者的试验报告的可用性,并有助于减少研究浪费。
更新日期:2019-12-02
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