The aim of this study was to determine if additional ¹⁸F-sodium fluoride PET/CT (NaF PET/CT) improves the prognostic accuracy in the initial staging of prostate cancer patients with normal bone scintigraphy undergoing prostatectomy. Methods: A prospective cohort study examined NaF PET/CT in intermediate- or high-risk prostate cancer with negative bone scintigraphy who were scheduled for prostatectomy. Biochemical response: PSA levels < 0.2 ng/mL at 6 wk and 6 mo postoperatively, PSA level ≥ 0.2 ng/mL was biochemical failure. Results: Eighty-one patients were included in the study; 75 patients (93%) achieved biochemical responses, 6 patients had biochemical failure. NaF PET/CT indicated bone metastasis in 1 patient (1.2%), was equivocal in 7 patients (8.6%), without bone metastases in 73 patients (90.1%). Eight patients with bone metastases or equivocal results on NaF PET/CT exhibited biochemical responses. All patients with biochemical failure had negative NaF PET/CT and bone scintigraphy for bone metastases. Conclusion: NaF PET/CT has no added value for bone staging in intermediate- and high-risk prostate cancer patients with normal bone scintigraphy results undergoing prostatectomy.

这项研究的目的是确定额外的¹⁸ F-氟化钠PET / CT（NaF PET / CT）是否能改善前列腺显像检查正常的前列腺癌患者在前列腺切除术中的初始分期。方法：一项前瞻性队列研究检查了NaF PET / CT在计划进行前列腺切除术的阴性或骨闪烁显像为阴性的中危或高危前列腺癌中的应用。生化反应：术后6 wk和6 mo PSA水平<0.2 ng / mL，PSA≥0.2 ng / mL是生化衰竭。结果：这项研究包括了八十一名患者。75名患者（93％）达到了生化反应，6名患者发生了生化失败。NaF PET / CT提示1例（1.2％）发生骨转移，7例（8.6％）不明确，73例（90.1％）无骨转移。在NaF PET / CT上有8例骨转移或模棱两可结果的患者表现出生化反应。所有生化衰竭患者的NaF PET / CT阴性，骨闪烁显像检查发现骨转移。结论： NaF PET / CT对中，高风险前列腺癌患者进行前列腺切除术后骨骼分期正常，对骨分期没有附加价值。