The LFER 150 PET/CT device (large–field-of-view extreme-resolution portable research imager) is a system for nonhuman primate (NHP) imaging. The objective of this study was to evaluate the performance of the system using the National Electrical Manufacturers Association NU 4-2008 standard protocol. As a preliminary in vivo evaluation of the system, a PET measurement in an NHP was also performed. Methods: Resolution, sensitivity, image quality, and noise-equivalent count rate (NECR) were measured. NECR measurement was performed with a ratlike phantom and a monkeylike phantom. A Derenzo phantom experiment was performed to test the resolution using 3-dimensional ordered-subset expectation maximization reconstruction. One cynomolgus monkey (4.5 kg, intravenous ketamine/xylazine anesthesia) was examined with the dopamine transporter radioligand ¹⁸F-FE-PE2I (94 MBq) to evaluate the in vivo performance of the system. List-mode PET data acquired for 93 min were reconstructed into 38 frames with the Tera-Tomo 3-dimensional engine. Binding potential for caudate nucleus, putamen, and substantia nigra was evaluated using the simplified reference tissue model. Results: Radial full-width half-maximum resolution using Fourier rebinning and a 2-dimensional filtered backprojection algorithm was less than 2.2 mm and less than 3.2 mm in the central 60-mm-diameter and 140-mm-diameter regions, respectively. Maximum sensitivity in the 400- to 600-keV and 250- to 750-keV energy windows was 30.03 cps/kBq (3.3%) and 49.11 cps/kBq (5.4%), respectively. The uniformity in the image-quality phantom was 3.3%, and the spillover ratio for air and water was 0.1. The peak of the NECR curve was 430 kcps (at 115 MBq) with the ratlike phantom and 78 kcps (at 139 MBq) with the monkeylike phantom. Rods of the Derenzo phantom with 1-mm diameter could be distinguished by eye. In the NHP experiment, binding potentials in the caudate, putamen, and substantia nigra (4.9, 4.9, and 1, respectively) were similar to those previously reported using the same radioligand and a high-resolution research tomograph. Conclusion: The results obtained from phantom experiments and 1 representative PET measurement in an NHP confirm that the LFER 150 is a high-resolution PET/CT system with suitable performance for brain imaging in NHPs.

LFER 150 PET / CT设备（大视野超高分辨率便携式研究成像仪）是用于非人类灵长类动物（NHP）成像的系统。这项研究的目的是使用美国国家电气制造商协会NU 4-2008标准协议评估系统的性能。作为系统的初步体内评估，还进行了NHP中的PET测量。方法：测量了分辨率，灵敏度，图像质量和等效噪声计数率（NECR）。用大鼠样幻影和猴子样幻影进行NECR测量。进行了Derenzo幻象实验，以使用3维有序子集期望最大化重建来测试分辨率。用多巴胺转运体放射性配体¹⁸ F-FE-PE2I（94 MBq）检查了一只食蟹猴（4.5 kg，静脉内氯胺酮/甲苯噻嗪麻醉），以评估系统的体内性能。使用Tera-Tomo 3维引擎将在93分钟内获得的列表模式PET数据重建为38帧。使用简化的参考组织模型评估了尾状核，壳核和黑质的结合潜力。结果：使用傅里叶重结合和二维滤波反投影算法的径向全角半最大分辨率在直径60毫米和直径140毫米的中央区域分别小于2.2 mm和小于3.2 mm。在400至600 keV和250至750 keV的能量窗口中，最大灵敏度分别为30.03 cps / kBq（3.3％）和49.11 cps / kBq（5.4％）。图像质量体模的均匀度为3.3％，空气和水的溢出率为0.1。NECR曲线的峰值在鼠形体模下为430 kcps（在115 MBq下），在猴形体模下为78 kcps（在139 MBq下）。用眼睛可以分辨出直径为1毫米的Derenzo幻影杆。在NHP实验中，尾状，壳状核和黑质中的结合电位（4.9、4.9和1，结论：从体模实验和NHP中的1个代表性PET测量获得的结果证实，LFER 150是一种高分辨率PET / CT系统，具有适合NHPs脑成像的性能。