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Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients.
The Pharmacogenomics Journal ( IF 2.8 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41397-019-0128-7
Guillermo Gervasini 1 , Guadalupe García-Pino 1, 2 , Sonia Mota-Zamorano 1 , Enrique Luna 3 , Montserrat García-Cerrada 4 , María Ángeles Tormo 5 , Juan José Cubero 3
Affiliation  

The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for LEPR rs1805094 and ADIPOQ rs1501299 and risk of graft loss were 0.35 (0.16–0.74) p = 0.006 and 2.37 (1.28–4.37) p = 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62), p = 0.005, and 2.43 (1.08–5.44), p = 0.031 for LEPR rs1805094 and ADIPOQ rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.



中文翻译:

瘦素和脂联素基因多态性与肾移植受者的长期预后的关系。

瘦素和脂联素基因中的多态性对肾移植长期预后的影响尚不清楚。在349位肾移植受者(RTR)中,我们旨在确定瘦素受体(LEPR)和脂联素(ADIPOQ)基因中的五个SNP与这些结果之间的关联。随访时间为2到25年(平均10.29±5.16年)。从分析中删除了两个SNP,表明它们与长期结局相关,并且在39 RTR后具有移植前发生心血管事件的历史后,其统计学显着性大大提高。调整比值比(OR)为LEPR rs1805094和ADIPOQ rs1501299和移植物丧失的风险分别为0.35(0.16-0.74)p 分别为0.006和2.37(1.28-4.37)p  = 0.006。全球死亡率风险的评估表明OR 0.20(0.06-0.62),值p  = 0.005,和2.43(1.08-5.44),p  = 0.031对LEPR rs1805094和ADIPOQ分别rs1501299。我们的结果表明,瘦素和脂联素功能相关基因的多态性改变了肾脏移植的长期结果。

更新日期:2019-12-02
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