当前位置: X-MOL 学术Anal. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Differential Pulse Voltammetric (DPV) Determination of the Local Anesthetic Bupivacaine using Polyimide Membrane-Based Electrodes
Analytical Letters ( IF 2 ) Pub Date : 2019-07-26 , DOI: 10.1080/00032719.2019.1646752
Öznur Güngör 1 , İmren Özcan 1 , Mehmet Ali Erdoğan 2 , Burhan Ateş 1 , Süleyman Köytepe 1
Affiliation  

Abstract Aromatic selective polyimide (PI) membrane based voltammetric electrodes were prepared for bupivacaine measurements. Polyimide membranes were synthesized from 4,4′-diaminobenzanilide (DABA) and different aromatic dianhydrides (pyromellitic dianhydride (PMDA), benzophenone-3,3′,4,4′-tetracarboxylic dianhydride (BPDA), 4,4′-oxydiphthalic anhydride (ODPA)) through two-step polycondenzation reactions. The structural properties of the obtained benzanilide based PIs were characterized by various analytical techniques. For the preparation of voltammetric electrodes, these polyimide films were coated with polyimide solution by drop-casting on the surface of a platinum working electrode. Due to the excellent film properties and suitable porosity, the prepared benzanilide based polyimide films were used as the membrane for selective determination of bupivacaine in the presence of interferents that included lactose, glucose and sucrose. For this reason, the selectivity of the modified electrode to bupivacaine obtained from the prepared PI film toward the potential interferences was investigated by differential pulse voltammetry (DPV). The results of voltammetric study showed that polyimide films responded to only bupivacaine at a potential of approximately +0.92 V. The polyimide membrane modified electrode showed a rapid response time, a high R-value of 0.9941, high reproducibility and good selectivity for bupivacaine. The limit of detection (LOD) and the limit of quantitation (LOQ) were determined to be 16.82 µM and 50.46 µM, respectively. Thus, benzanilide based polyimides may be successfully used as selective membranes for preparation of bupivacaine sensors. This structure may be a precursor for the preparation of simultaneous or needle-shaped sensors in the future.

中文翻译:

使用聚酰亚胺膜电极测定局麻药布比卡因的差分脉冲伏安 (DPV)

摘要 制备了用于布比卡因测量的基于芳香族选择性聚酰亚胺 (PI) 膜的伏安电极。聚酰亚胺膜由 4,4'-二氨基苯甲酰苯胺 (DABA) 和不同的芳香族二酐(均苯四甲酸二酐 (PMDA)、二苯甲酮-3,3',4,4'-四羧酸二酐 (BPDA)、4,4'-氧二邻苯二甲酸酐)合成(ODPA)) 通过两步缩聚反应。获得的基于苯甲酰苯胺的 PI 的结构特性通过各种分析技术进行表征。为了制备伏安电极,通过在铂工作电极的表面上滴铸,将这些聚酰亚胺薄膜涂上聚酰亚胺溶液。由于优异的成膜性能和合适的孔隙率,制备的苯甲酰苯胺基聚酰亚胺薄膜用作膜,在存在干扰物(包括乳糖、葡萄糖和蔗糖)的情况下选择性测定布比卡因。因此,通过差分脉冲伏安法 (DPV) 研究了修饰电极对从制备的 PI 膜中获得的布比卡因对潜在干扰的选择性。伏安法研究结果表明,聚酰亚胺薄膜仅在约 +0.92 V 的电位下对布比卡因有响应。聚酰亚胺膜修饰电极显示出响应时间快、R 值高(0.9941)、高重现性和对布比卡因的良好选择性。检测限 (LOD) 和定量限 (LOQ) 分别确定为 16.82 µM 和 50.46 µM。因此,基于苯甲酰苯胺的聚酰亚胺可成功用作制备布比卡因传感器的选择性膜。这种结构可能是未来制备同步或针状传感器的先驱。
更新日期:2019-07-26
down
wechat
bug