当前位置: X-MOL 学术BBA Mol. Cell Biol. Lipids › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ( IF 4.8 ) Pub Date : 2019-11-30 , DOI: 10.1016/j.bbalip.2019.158579
Yuting Wang 1 , Sebastian Hinz 2 , Ortrud Uckermann 3 , Pia Hönscheid 4 , Witigo von Schönfels 2 , Greta Burmeister 2 , Alexander Hendricks 2 , Jacobo Miranda Ackerman 5 , Gustavo B Baretton 4 , Jochen Hampe 6 , Mario Brosch 6 , Clemens Schafmayer 2 , Andrej Shevchenko 5 , Sebastian Zeissig 6
Affiliation  

Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-associated lipidome alterations in the tumor tissue has not emerged. Here, we determined molar abundances of 342 species from 20 lipid classes in matched biopsies of CRC and adjacent normal mucosa. We demonstrate that in contrast to previous reports, CRC shows a largely preserved lipidome composition that resembles that of normal colonic mucosa. Important exceptions include increased levels of lyso-phosphatidylinositols in CRC and reduced abundance of ether phospholipids in advanced stages of CRC. As such, our observations challenge the concept of widespread alterations in lipid metabolism in CRC and rather suggest changes in the cellular lipid profile that are limited to selected lipids involved in signaling and the scavenging of reactive oxygen species.

中文翻译:

基于弹枪脂质组学的大肠癌脂质代谢景观表征。

实体瘤的特征是整体代谢改变,这有助于其生长和发展。基因表达谱和血浆脂质成分的改变提示了在结肠直肠癌(CRC)发育中代谢重编程的作用。但是,尚未出现肿瘤组织中CRC相关脂质组改变的结论性图片。在这里,我们从CRC和邻近正常黏膜的活检组织中确定了来自20种脂质类别的342种物种的摩尔丰度。我们证明,与以前的报道相反,CRC显示出与正常结肠粘膜相似的很大程度上保留的脂质组组成。重要的例外包括CRC中溶血磷脂酰肌醇的水平升高,以及在CRC晚期阶段降低了醚磷脂的丰度。因此,
更新日期:2019-11-30
down
wechat
bug