Group 2 innate lymphoid cells (ILC2s) mediate allergic immunity but have also recently come into focus as key sentinels of tissue health and homeostasis. Clues as to how these rare immune cells coordinate tissue-wide responses to perturbation have emerged from deciphering the communication between ILC2s and an ever-expanding list of diverse nonhematopoietic cells. High-resolution tracking and profiling approaches have accelerated these efforts, revealing ILC2 transcriptional programs that are coordinated with tissue and organism development. We propose that the engagement of these homeostatic feedback circuits by internal and external cues forms the basis for how tissues instruct type 2 immunity. Understanding how these normally restorative networks become unbalanced may be crucial in devising appropriately targeted therapies for allergic diseases.

中文翻译：

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高清晰度的ILC2：解码基于组织的免疫的逻辑。

第2组先天性淋巴样细胞（ILC2）介导过敏性免疫，但最近也成为组织健康和体内平衡的重要前哨。关于这些稀有免疫细胞如何协调组织范围内对扰动的反应的线索，已经从破译ILC2s和种类繁多的非造血细胞之间不断的交流中脱颖而出。高分辨率跟踪和分析方法加快了这些工作，揭示了与组织和生物体发育相协调的ILC2转录程序。我们建议内部和外部提示参与这些稳态反馈电路，构成组织如何指示2型免疫力的基础。了解这些正常恢复性网络是如何变得不平衡的，对于设计针对性的过敏性疾病疗法至关重要。