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The blood-brain barrier: Physiology and strategies for drug delivery.
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2019-11-29 , DOI: 10.1016/j.addr.2019.11.009
Rucha Pandit 1 , Liyu Chen 1 , Jürgen Götz 1
Affiliation  

The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper, reflecting the unique requirements of the brain. In this review, following a brief historical overview of how the concepts of the BBB and the neurovascular unit (NVU) developed, we describe its physiology and architecture, which pose a particular challenge to therapeutic intervention. We then discuss how the restrictive nature of this barrier can be overcome for the delivery of therapeutic agents. Alterations to drug formulation offer one option, in part by utilizing distinct transport modes; another is invasive or non-invasive strategies to bypass the BBB. An emerging non-invasive technology for targeted drug delivery is focused ultrasound that allows for the safe and reversible disruption of the BBB. We discuss the underlying mechanisms and provide an outlook, emphasizing the need for more research into the NVU and investment in innovative technologies to overcome the BBB for drug delivery.

中文翻译:

血脑屏障:药物输送的生理学和策略。

血脑屏障 (BBB) 是一种动态结构,具有看门人的功能,反映了大脑的独特需求。在这篇综述中,在对 BBB 和神经血管单元 (NVU) 的概念如何发展的简要历史概述之后,我们描述了其生理学和结构,这对治疗干预构成了特殊挑战。然后,我们讨论如何克服这种障碍的限制性质来递送治疗剂。改变药物配方提供了一种选择,部分是通过利用不同的运输方式;另一种是绕过 BBB 的侵入性或非侵入性策略。一种用于靶向给药的新兴非侵入性技术是聚焦超声,它可以安全、可逆地破坏 BBB。我们讨论了潜在的机制并提供了一个展望,
更新日期:2020-04-20
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