New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.

中文翻译：

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海洋海绵海绵体中的变色素X和Y。及其对细胞周期进程的影响。

分离出新的倍半萜醌，变色素X（1）和Y（2）以及已知的变色素C（3），J（4）和T（5）作为HeLa / Fucci2细胞中细胞周期进程的抑制剂。1的结构由光谱数据确定，并通过总合成得到证实。2的平面结构是通过光谱数据的解释来确定的，而其绝对构型则是通过手性HPLC和CD光谱的结合来分析的。变色素X（1）和C（3）在S / G2 / M期阻止了HeLa / Fucci2细胞的细胞周期进程。