Therapeutic and prophylactic deletion of IL‐4Rα‐signaling ameliorates established ovalbumin induced allergic asthma,Allergy

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Therapeutic and prophylactic deletion of IL‐4Rα‐signaling ameliorates established ovalbumin induced allergic asthma
Allergy ( IF 12.4 ) Pub Date : 2020-01-30 , DOI: 10.1111/all.14137
Jermaine Khumalo _{1,

2} , Frank Kirstein ₁ , Martyna Scibiorek _{1,

2} , Sabelo Hadebe ₁ , Frank Brombacher _{1,

2,

3}

Affiliation

Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. IL‐4Rα‐signaling is essential for driving TH2‐type immunity to allergens. Anti‐TH2 therapies have the potential to effectively reduce airway obstruction and inflammation in allergic asthma.

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