A new study presents a powerful experimental approach, CRISPRi-FlowFISH, for mapping regulatory interactions, and uses it to characterize thousands of putative enhancer–gene pairs. The results suggest that most current approaches for predicting enhancer–gene interactions perform poorly, but a simple mathematical model combining distance with enhancer activity shows promise.

中文翻译：

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映射和预测基因增强子的相互作用。

一项新研究提出了一种强大的实验方法CRISPRi-FlowFISH，用于定位调节相互作用，并用它来表征数千种推定的增强子-基因对。结果表明，目前大多数预测增强子与基因相互作用的方法均表现不佳，但是将距离与增强子活性结合起来的简单数学模型显示出了希望。