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Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women.
Metabolism ( IF 9.8 ) Pub Date : 2019-11-29 , DOI: 10.1016/j.metabol.2019.154043 Dalia Malkova 1 , Thelma Polyviou 2 , Eleni Rizou 1 , Konstantinos Gerasimidis 1 , Edward S Chambers 3 , Tom Preston 4 , M Catriona Tedford 5 , Gary Frost 3 , Douglas J Morrison 4
Metabolism ( IF 9.8 ) Pub Date : 2019-11-29 , DOI: 10.1016/j.metabol.2019.154043 Dalia Malkova 1 , Thelma Polyviou 2 , Eleni Rizou 1 , Konstantinos Gerasimidis 1 , Edward S Chambers 3 , Tom Preston 4 , M Catriona Tedford 5 , Gary Frost 3 , Douglas J Morrison 4
Affiliation
BACKGROUND
Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on energy substrate utilisation are unknown. The aim of this study was to investigate the impact of 4-weeks IPE supplementation, in combination with a moderate intensity exercise training programme, on whole body fat oxidation and on plasma GLP-1 and PYY.
METHODS
Twenty overweight healthy women participated in randomised parallel study and underwent 4 weeks of supervised exercise training either with IPE (EX/IPE group) or Placebo (EX/Placebo group) supplementation. Before and after the intervention participants conducted an experimental trial, which involved collection of expired gas and blood samples in the fasted state and during 7 h of the postprandial state.
RESULTS
Within groups, the EX/IPE group significantly enhanced the amount of fat (Pre, 24.1 ± 1.2 g; Post, 35.9 ± 4.0 g, P < 0.05) oxidised and reduced CHO (Pre, 77.8 ± 6.0 g; Post, 57.8 ± 7.7 g, P < 0.05) oxidised, reduced body weight (Pre, 77.3 ± 4.2 kg; Post, 76.6 ± 4.1 kg, P < 0.05) and body fat mass (Pre, 37.7 ± 1.9%; Post, 36.9 ± 1.9%, P < 0.05). In EX/Placebo group, changes in amount of fat (Pre, 36.8 ± 3.9 g; Post, 37.0 ± 4.0 g) and CHO (Pre, 62.7 ± 6.5 g; Post, 61.5 ± 7.4 g) oxidised, body weight (Pre, 84.2 ± 4.3 kg; Post, 83.6 ± 4.3 kg) and body fat mass (Pre, 40.1 ± 1.9%; Post, 38.7 ± 1.5%) were not significant (P > 0.05). Comparing between groups, changes in the amount of fat oxidised were significantly (P < 0.05) different and a trend for difference was observed for amount of CHO oxidised (P = 0.06) and RER (P = 0.06). The interventions had no impact on fasting or postprandial plasma concentrations of GLP-1 and PYY.
CONCLUSION
Moderate intensity exercise training programmes when combined with daily oral IPE supplementation may help overweight women to achieve increase in fat oxidation. The study was registered at clinicaltrials.gov as NCT04016350.
中文翻译:
中等强度的运动训练加上菊粉-丙酸酯的补充会增加超重女性的全身静息脂肪氧化。
背景技术我们以前的工作表明,口服菊粉丙酸酯(IPE)补充剂可减少腹部脂肪并防止体重增加,口服丙酸酯的摄入可增强静息脂肪的氧化。IPE结合运动训练对能量底物利用率的影响尚不清楚。这项研究的目的是调查为期4周的IPE补充疗法,结合中等强度的运动训练计划,对全身脂肪氧化以及血浆GLP-1和PYY的影响。方法20名超重健康女性参加了随机平行研究,并接受了IPE(EX / IPE组)或安慰剂(EX /安慰剂组)补充治疗,接受了为期4周的有监督运动训练。在干预参与者进行实验之前和之后,其中包括在禁食状态和餐后7小时内收集过期的气体和血液样本。结果在各组中,EX / IPE组显着增加了脂肪的氧化(Pre,24.1±1.2 g; Post,35.9±4.0 g,P <0.05),氧化并降低了CHO(Pre,77.8±6.0 g; Post,57.8± 7.7 g,P <0.05)被氧化,减轻体重(之前,77.3±4.2 kg;后,76.6±4.1 kg,P <0.05)和身体脂肪量(之前,37.7±1.9%;后,36.9±1.9%, P <0.05)。在EX /安慰剂组中,被氧化的脂肪量(Pre,36.8±3.9 g; Post,37.0±4.0 g)和CHO(Pre,62.7±6.5 g; Post,61.5±7.4 g)的氧化被改变,体重(Pre, 84.2±4.3公斤;后期,83.6±4.3公斤)和体脂质量(之前,40.1±1.9%;后期,38.7±1.5%)不显着(P> 0.05)。组之间的比较 脂肪氧化量的变化显着(P <0.05),并且观察到CHO氧化量(P = 0.06)和RER(P = 0.06)的变化趋势。干预对空腹或餐后血浆GLP-1和PYY浓度没有影响。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。
更新日期:2019-11-30
中文翻译:
中等强度的运动训练加上菊粉-丙酸酯的补充会增加超重女性的全身静息脂肪氧化。
背景技术我们以前的工作表明,口服菊粉丙酸酯(IPE)补充剂可减少腹部脂肪并防止体重增加,口服丙酸酯的摄入可增强静息脂肪的氧化。IPE结合运动训练对能量底物利用率的影响尚不清楚。这项研究的目的是调查为期4周的IPE补充疗法,结合中等强度的运动训练计划,对全身脂肪氧化以及血浆GLP-1和PYY的影响。方法20名超重健康女性参加了随机平行研究,并接受了IPE(EX / IPE组)或安慰剂(EX /安慰剂组)补充治疗,接受了为期4周的有监督运动训练。在干预参与者进行实验之前和之后,其中包括在禁食状态和餐后7小时内收集过期的气体和血液样本。结果在各组中,EX / IPE组显着增加了脂肪的氧化(Pre,24.1±1.2 g; Post,35.9±4.0 g,P <0.05),氧化并降低了CHO(Pre,77.8±6.0 g; Post,57.8± 7.7 g,P <0.05)被氧化,减轻体重(之前,77.3±4.2 kg;后,76.6±4.1 kg,P <0.05)和身体脂肪量(之前,37.7±1.9%;后,36.9±1.9%, P <0.05)。在EX /安慰剂组中,被氧化的脂肪量(Pre,36.8±3.9 g; Post,37.0±4.0 g)和CHO(Pre,62.7±6.5 g; Post,61.5±7.4 g)的氧化被改变,体重(Pre, 84.2±4.3公斤;后期,83.6±4.3公斤)和体脂质量(之前,40.1±1.9%;后期,38.7±1.5%)不显着(P> 0.05)。组之间的比较 脂肪氧化量的变化显着(P <0.05),并且观察到CHO氧化量(P = 0.06)和RER(P = 0.06)的变化趋势。干预对空腹或餐后血浆GLP-1和PYY浓度没有影响。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。结论适度的强度运动训练计划与每日口服IPE补充相结合,可能有助于超重的女性实现脂肪氧化的增加。该研究已在Clinicaltrials.gov上注册为NCT04016350。