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Central blood pressure and pulse wave velocity in young and middle-aged Japanese adults with isolated systolic hypertension
Hypertension Research ( IF 5.4 ) Pub Date : 2019-11-29 , DOI: 10.1038/s41440-019-0364-x Atsushi Nakagomi 1 , Fumio Imazeki 2 , Motoi Nishimura 3 , Yuji Sawabe 3 , Kazuyuki Matsushita 3 , Akitoshi Murata 4 , Mariko Watase 5 , Sho Okada 1 , Yoshio Kobayashi 1
Hypertension Research ( IF 5.4 ) Pub Date : 2019-11-29 , DOI: 10.1038/s41440-019-0364-x Atsushi Nakagomi 1 , Fumio Imazeki 2 , Motoi Nishimura 3 , Yuji Sawabe 3 , Kazuyuki Matsushita 3 , Akitoshi Murata 4 , Mariko Watase 5 , Sho Okada 1 , Yoshio Kobayashi 1
Affiliation
Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mmHg and diastolic BP (DBP) <90 mmHg, is a common type of hypertension among young men. This study aimed to investigate the clinical characteristics, central blood pressure, and arterial stiffness of young and middle-aged Japanese individuals with ISH. A total of 432 male participants, aged 18–49 years, were classified into six subgroups: optimal BP (SBP <120 mmHg and DBP <80 mmHg), high-normal BP (SBP 120–129 mmHg and DBP <80 mmHg), high-BP (SBP 130–139 mmHg and/or DBP 80–89 mmHg), ISH (SBP ≥140 mmHg and DBP <90 mmHg), isolated diastolic hypertension (IDH) (SBP <140 mmHg and DBP ≥90 mmHg), and systolic and diastolic hypertension (SDH) (SBP ≥140 mmHg and DBP ≥90 mmHg). Participants with ISH had a greater body mass index (BMI) and waist circumference than the optimal BP participants but were more likely to be physically active than the IDH and SDH participants. The central SBP of the ISH subgroup was higher than that of the optimal/high-normal/high-BP subgroups and lower than that of the SDH subgroup. The carotid–femoral pulse wave velocity (cfPWV) of the ISH subgroup was higher than that of the optimal and high-normal BP subgroups and lower than that of the SDH subgroup after adjusting for age, heart rate, BMI, and physical activity. These differences disappeared after further adjustment for central mean arterial pressure. In conclusion, the central SBP of Japanese men with ISH was greater than that of Japanese men with optimal/high-normal/high-BP, but the progression of arterial stiffness was unclear.
中文翻译:
日本中青年单纯收缩期高血压的中心血压和脉搏波速度
孤立性收缩期高血压 (ISH),定义为收缩压 (SBP) ≥ 140 mmHg 和舒张压 (DBP) < 90 mmHg,是年轻男性常见的高血压类型。本研究旨在调查日本年轻和中年 ISH 患者的临床特征、中心血压和动脉僵硬度。共有 432 名年龄在 18-49 岁之间的男性参与者被分为六个亚组:最佳血压(SBP <120 mmHg 和 DBP <80 mmHg)、正常高血压(SBP 120-129 mmHg 和 DBP <80 mmHg)、高血压(SBP 130-139 mmHg 和/或 DBP 80-89 mmHg)、ISH(SBP ≥ 140 mmHg 和 DBP <90 mmHg)、孤立性舒张期高血压(IDH)(SBP <140 mmHg 和 DBP ≥90 mmHg),收缩压和舒张压高血压 (SDH)(SBP ≥ 140 mmHg 和 DBP ≥ 90 mmHg)。ISH 参与者的体重指数 (BMI) 和腰围高于最佳 BP 参与者,但比 IDH 和 SDH 参与者更有可能进行体育锻炼。ISH亚组的中心收缩压高于最佳/高正常/高BP亚组,低于SDH亚组。在调整年龄、心率、BMI 和体力活动后,ISH 亚组的颈股脉搏波速度 (cfPWV) 高于最佳和正常高血压亚组,低于 SDH 亚组。在进一步调整中心平均动脉压后,这些差异消失了。总之,日本 ISH 男性的中心 SBP 高于最佳/正常高/高 BP 的日本男性,但动脉僵硬的进展尚不清楚。
更新日期:2019-11-29
中文翻译:
日本中青年单纯收缩期高血压的中心血压和脉搏波速度
孤立性收缩期高血压 (ISH),定义为收缩压 (SBP) ≥ 140 mmHg 和舒张压 (DBP) < 90 mmHg,是年轻男性常见的高血压类型。本研究旨在调查日本年轻和中年 ISH 患者的临床特征、中心血压和动脉僵硬度。共有 432 名年龄在 18-49 岁之间的男性参与者被分为六个亚组:最佳血压(SBP <120 mmHg 和 DBP <80 mmHg)、正常高血压(SBP 120-129 mmHg 和 DBP <80 mmHg)、高血压(SBP 130-139 mmHg 和/或 DBP 80-89 mmHg)、ISH(SBP ≥ 140 mmHg 和 DBP <90 mmHg)、孤立性舒张期高血压(IDH)(SBP <140 mmHg 和 DBP ≥90 mmHg),收缩压和舒张压高血压 (SDH)(SBP ≥ 140 mmHg 和 DBP ≥ 90 mmHg)。ISH 参与者的体重指数 (BMI) 和腰围高于最佳 BP 参与者,但比 IDH 和 SDH 参与者更有可能进行体育锻炼。ISH亚组的中心收缩压高于最佳/高正常/高BP亚组,低于SDH亚组。在调整年龄、心率、BMI 和体力活动后,ISH 亚组的颈股脉搏波速度 (cfPWV) 高于最佳和正常高血压亚组,低于 SDH 亚组。在进一步调整中心平均动脉压后,这些差异消失了。总之,日本 ISH 男性的中心 SBP 高于最佳/正常高/高 BP 的日本男性,但动脉僵硬的进展尚不清楚。