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One-Pot Access to 2-Aryl-3-(arylmethyl)chromones
Synthesis ( IF 2.6 ) Pub Date : 2019-11-28 , DOI: 10.1055/s-0039-1690760
Meng-Yang Chang 1, 2 , Kuan-Ting Chen 1 , Yu-Lin Tsai 1 , Han-Yu Chen 1
Affiliation  

Sodium hydroxide controlled intermolecular double aldol condensation of o-hydroxyacetophenones with 2 equivalents of aryl­aldehydes provides 2-aryl-3-(arylmethyl)chromones (a chimera of flavone and homoisoflavanone) in MeOH at 50 °C under mild conditions. The uses of various bases and solvents are investigated for one-pot facile and efficient transformation. A plausible mechanism is proposed.

中文翻译:

一锅获得2-芳基-3-(芳基甲基)色酮

位羟基苯乙酮与2当量芳基醛的氢氧化钠控制的分子间双羟醛缩合反应可在温和条件下于MeOH中于50°C的条件下提供2-芳基-3-(芳基甲基)色酮(黄酮和均异黄烷酮的嵌合体)。研究了各种碱和溶剂的使用,以实现一锅式便捷高效转化。提出了一个合理的机制。
更新日期:2019-11-29
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