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Bioactive peptides attenuate cardiac hypertrophy and fibrosis in spontaneously hypertensive rat hearts
Journal of Food and Drug Analysis ( IF 3.6 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.jfda.2019.11.002
Chih Yang Huang , Srinivasan Nithiyanantham , Jia Ying Liao , Wan Teng Lin

Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might an have important role in anti-obesity activity. Recent studies from our lab indicated that APPH treatment had lipolysis stimulating activity and identified was an efficient anti-obesity diet ingredient. In this study we aim to investigate the beneficial effects of pure peptide amino acid sequences (DIKTNKPVIF (DI) and IF) from APPH supplement in the regulation of cardiac hypertrophy and fibrosis on spontaneously hypertensive rats (SHR). We examined hematoxylin and eosin staining, Masson's trichrome staining, echocardiographic parameters, serum parameters, hypertrophy, inflammation and fibrotic marker expression to demonstrate efficacy of bioactive peptides in a SHR model. There was a significant upregulation between SHR and bioactive peptides treated groups in left heart weight (LHW), LHW/WHW, LHW/Tibia, LVIDd, and LVd mass. In addition, the bioactive peptides repress the protein expression of hypertrophy markers (BNP, MYH7), inflammation (TLR-4, p-NFkB, TNF-α, IL-6), and fibrotic markers (uPA, MMP-2, TIMP1, CTGF). In summary, these results indicate that DI and IF bioactive peptides from APPH attenuate cardiac hypertrophy, inflammation and fibrosis in the SHR model.

中文翻译:

生物活性肽减轻自发性高血压大鼠心脏的心肌肥厚和纤维化

Alcalase 马铃薯蛋白水解物 (APPH) 是一种营养食品,可能在抗肥胖活性中具有重要作用。我们实验室最近的研究表明,APPH 治疗具有刺激脂肪分解的活性,并被确定为一种有效的抗肥胖饮食成分。在本研究中,我们旨在研究来自 APPH 补充剂的纯肽氨基酸序列(DIKTNKPVIF(DI)和 IF)在调节自发性高血压大鼠(SHR)心脏肥大和纤维化方面的有益作用。我们检查了苏木精和伊红染色、马森三色染色、超声心动图参数、血清参数、肥大、炎症和纤维化标志物表达,以证明生物活性肽在 SHR 模型中的功效。在左心重量 (LHW)、LHW/WHW、LHW/胫骨、LVIDd 和 LVd 质量方面,SHR 和生物活性肽治疗组之间存在显着上调。此外,生物活性肽抑制肥大标志物(BNP、MYH7)、炎症(TLR-4、p-NFkB、TNF-α、IL-6)和纤维化标志物(uPA、MMP-2、TIMP1、 CTGF)。总之,这些结果表明来自 APPH 的 DI 和 IF 生物活性肽可减轻 SHR 模型中的心脏肥大、炎症和纤维化。
更新日期:2020-01-01
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