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Who’s in charge here? Macrophage colony stimulating factor and granulocyte macrophage colony stimulating factor: Competing factors in macrophage polarization
Cytokine ( IF 3.8 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.cyto.2019.154939
Evan Trus 1 , Sameh Basta 1 , Katrina Gee 1
Affiliation  

Macrophages make up a crucial aspect of the immune system, carrying out a variety of functions ranging from clearing cellular debris to their well-recognized roles as innate immune cells. These cells exist along a spectrum of phenotypes but can be generally divided into proinflammatory (M1) and anti-inflammatory (M2) groups, representing different states of polarization. Due to their diverse functions, macrophages are implicated in a variety of diseases such as atherosclerosis, lupus nephritis, or infection with HIV. Throughout their lifetime, macrophages can be influenced by a wide variety of signals that influence their polarization states, which can affect their function and influence their effects on disease progression. This review seeks to provide a summary of how GM-CSF and M-CSF influence macrophage activity during disease, and provide examples of in vitro research that indicate competition between the two cytokines in governing macrophage polarization. Gaining a greater understanding of the relationship between GM-CSF and M-CSF, along with how these cytokines fit into the larger context of diseases, will inform their use as treatments or targets for treatment in various diseases.

中文翻译:

谁在这里负责?巨噬细胞集落刺激因子和粒细胞巨噬细胞集落刺激因子:巨噬细胞极化的竞争因素

巨噬细胞构成了免疫系统的一个重要方面,执行各种功能,从清除细胞碎片到它们作为先天免疫细胞的公认作用。这些细胞存在于一系列表型中,但通常可以分为促炎 (M1) 和抗炎 (M2) 组,​​代表不同的极化状态。由于其功能多样,巨噬细胞与多种疾病有关,例如动脉粥样硬化、狼疮性肾炎或 HIV 感染。在其一生中,巨噬细胞会受到影响其极化状态的多种信号的影响,这些信号会影响其功能并影响其对疾病进展的影响。本综述旨在总结 GM-CSF 和 M-CSF 如何影响疾病期间的巨噬细胞活性,并提供体外研究的例子,表明两种细胞因子在控制巨噬细胞极化方面的竞争。更深入地了解 GM-CSF 和 M-CSF 之间的关系,以及这些细胞因子如何适应更大的疾病背景,将有助于了解它们作为各种疾病的治疗方法或治疗靶点。
更新日期:2020-03-01
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