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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.
Chemico-Biological Interactions ( IF 5.1 ) Pub Date : 2019-11-28 , DOI: 10.1016/j.cbi.2019.108911
Yinghan Chan 1 , Sin Wi Ng 1 , Joycelin Zhu Xin Tan 1 , Gaurav Gupta 2 , Murtaza M Tambuwala 3 , Hamid A Bakshi 3 , Harish Dureja 4 , Kamal Dua 5 , Muhammad Ishaq 6 , Vanni Caruso 7 , Dinesh Kumar Chellappan 8
Affiliation  

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.

中文翻译:

虹彩状分子阿斯普洛苷的新兴治疗潜力:其潜在分子机制的简要介绍。

多年来,现代药物发现和开发领域的研究人员对从植物来源和传统药物中鉴定活性化合物的关注变得更加强烈,因为它们显示出更高的治疗功效和更强的毒理学特征。在因其潜在的治疗益处而被发现和探索的多种植物提取物中,阿斯普洛糖苷(一种类环烷苷)已被证明可作为多种疾病的治疗剂提供有希望的作用。尽管这种有效物质存在于多个属中,但主要在杜仲属植物中发现。近几十年来,阿斯普洛苷的研究激增,使其成为医学和药理学领域研究最多的天然产物之一。在这篇评论中,
更新日期:2019-11-28
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