Clutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. The structures of the undescribed compounds were elucidated from their 2D NMR and MS spectra. Single crystal X-ray analyses confirmed the structures of eleven compounds. As, in Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride.

中文翻译：

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从 Clutia lanceolata Forssk 中分离的 5-甲基香豆素及其硫类似物刺激胰岛素分泌

Clutia lanceolata Forssk。(C. lanceolata) 是一种原产于撒哈拉以南非洲和阿拉伯半岛的药用植物。C. lanceolata 地上部分的植物化学研究产生了 21 种香豆素，包括甲硫基香豆素和甲亚磺酰基香豆素。这些化合物中有 13 种是首次报道，命名为 cluteolin A 到 M。其余 8 种化合物是已知的，但之前未与 C. lanceolata 相关联。未描述的化合物的结构由其 2D NMR 和 MS 光谱阐明。单晶 X 射线分析证实了 11 种化合物的结构。由于在沙特阿拉伯的传统中，C. lanceolata 已被报道具有抗糖尿病和抗真菌特性，因此检查了香豆素的生物活性。