Although Kraken’s k-mer-based approach provides a fast taxonomic classification of metagenomic sequence data, its large memory requirements can be limiting for some applications. Kraken 2 improves upon Kraken 1 by reducing memory usage by 85%, allowing greater amounts of reference genomic data to be used, while maintaining high accuracy and increasing speed fivefold. Kraken 2 also introduces a translated search mode, providing increased sensitivity in viral metagenomics analysis.

中文翻译：

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使用 Kraken 2 改进宏基因组分析

尽管 Kraken 的基于 k-mer 的方法提供了宏基因组序列数据的快速分类学分类，但它的大内存需求可能会限制某些应用程序。Kraken 2 通过将内存使用量减少 85% 来改进 Kraken 1，允许使用更多的参考基因组数据，同时保持高精度并将速度提高五倍。Kraken 2 还引入了翻译搜索模式，提高了病毒宏基因组分析的灵敏度。