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**Unidirectional large-amplitude oscillatory shear flow of human blood**

*Applied Physics Reviews*( IF 17.054 )

**Pub Date : 2019-11-12**

*, DOI:*

*10.1063/1.5127868*

Chaimongkol Saengow, Alan Jeffrey Giacomin, Andrea Stephanie Dimitrov

Blood is a non-Newtonian suspension of red and white cells, platelets, fibrinogen, and cholesterols in Newtonian plasma. To assess its non-Newtonian behaviors, this work considers a newly proposed blood test, unidirectional large-amplitude oscillatory shear flow (

更新日期：2019-11-28
*ud*LAOS). In the laboratory, we generate this experiment by superposing LAOS onto steady shear flow in such a way that the shear rate never changes sign. It is thus intended to best represent the unidirectional pulsatile flow in veins and arteries. To model human blood, we consider the simplest model that can predict infinite-shear viscosity, the corotational Jeffreys fluid. We arrive at an exact analytical expression for the shear stress response of this model fluid. We discover fractional harmonics comprising the transient part of the shear stress response and both integer and fractional harmonics, the alternant part. By*fractional*, we mean that these occur at frequencies other than integer multiples of the superposed oscillation frequency. We generalize the corotational Jeffreys fluid to multimode to best represent three blood samples from three healthy but different donors. To further improve our model predictions, we consider the multimode Oldroyd 8-constant framework, which contains the corotational Jeffreys fluid as a special case. In other words, by advancing from the multimode corotational Jeffreys fluid to the multimode Oldroyd 8-constant framework, five more model parameters are added, yielding better predictions. We find that the multimode corotational Jeffreys fluid adequately describes the steady shear viscosity functions measured for three different healthy donors. We further find that adding two more specific nonlinear constants to the multimode corotational Jeffreys fluid also adequately describes the behaviors of these same bloods in*ud*LAOS. This new Oldroyd 5-constant model may find usefulness in monitoring health through*ud*LAOS.