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Vitamin D status in Africa is worse than in other continents.
The Lancet Global Health ( IF 34.3 ) Pub Date : 2019-11-27 , DOI: 10.1016/s2214-109x(19)30492-9 Roger Bouillon 1
The Lancet Global Health ( IF 34.3 ) Pub Date : 2019-11-27 , DOI: 10.1016/s2214-109x(19)30492-9 Roger Bouillon 1
Affiliation
Serum concentration of 25-hydroxyvitamin D (25[OH]D) is the best marker for nutritional vitamin D status. Although no consensus has been reached on the optimal 25(OH)D concentration, all guidelines agree that serum 25(OH)D concentrations of less than 30 nmol/L (12 ng/mL) should be avoided in all age groups. Several reviews of vitamin D status have concluded that vitamin D deficiency is highly prevalent around the world, yet Africa is considered to be largely spared from severe vitamin D deficiency., A global review of serum 25(OH)D concentrations found that concentrations of less than 30 nmol/L are present in around 7% of the global population. Severe vitamin D deficiency affects around 5% of the US population (based on a representative sample from the National Health and Nutrition Examination Survey 2011–14), 14% of individuals in Europe (based on 11 randomised controlled trials), and a higher percentage of people living in the Middle East or Gulf states. Severe vitamin D deficiency has also been observed in Northern India and China. In The Lancet Global Health, Reagan M Mogire and colleagues describe the vitamin D status of 21 474 individuals living in 23 African countries. Severe vitamin D deficiency (<30 nmol/L 25[OH]D) was found in about 18% of these individuals, suggesting that Africa could be the continent with the highest frequency of severe vitamin D deficiency (). This finding is in contrast with the widely held view that the extensive sunshine in Africa, the cradle of mankind, was indicative for the optimal vitamin D status of early humans. The study by Mogire and colleagues has some major limitations, in that it does not evaluate a representative sample of the African population, does not use accuracy-validated assays, and overrepresents North African countries and South Africa, with no data on many African countries. Nevertheless, the study does improve our global view of vitamin D deficiency.
更新日期：2019-12-13
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