Resting-state functional magnetic resonance imaging studies using a regional homogeneity (ReHo) method have reported that amnestic mild cognitive impairment (aMCI) was associated with abnormalities in local functional connectivity. However, their results were not conclusive. Seed-based d Mapping was used to conduct a coordinate-based meta-analysis to identify consistent ReHo alterations in aMCI. We identified 10 studies with 11 datasets suitable for inclusion, including 378 patients with aMCI and 435 healthy controls. This meta-analysis identified significant ReHo alterations in patients with aMCI relative to healthy controls, mainly within the default mode network (DMN) (bilateral posterior cingulate cortex [PCC], right angular gyrus, bilateral middle temporal gyri, and left parahippocampal gyrus/hippocampus), executive control network (right superior parietal lobule and dorsolateral prefrontal cortex), visual network (right lingual gyrus and left middle occipital gyrus), and sensorimotor network (right paracentral lobule/supplementary motor area, right postcentral gyrus and left posterior insula). Significant heterogeneity of ReHo alterations in the bilateral PCC, left parahippocampal gyrus/hippocampus, and right superior parietal lobule/angular gyrus was observed. Exploratory meta-regression analyses indicated that general cognitive function, gender distribution, age, and education level partially contributed to this heterogeneity. This study provides provisional evidence that aMCI is associated with abnormal ReHo within the DMN, executive control network, visual network, and sensorimotor network. These local functional connectivity alterations suggest coexistence of functional deficits and compensation in these networks. These findings contribute to the modeling of brain functional connectomes and to a better understanding of the neural substrates of aMCI. Confounding factors merit much attention and warrant future investigations.

中文翻译：

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遗忘型轻度认知障碍患者大脑局部功能连接的改变

使用区域同质性 (ReHo) 方法的静息状态功能磁共振成像研究报告说，遗忘性轻度认知障碍 (aMCI) 与局部功能连接异常有关。然而，他们的结果并没有定论。基于种子的 d 映射用于进行基于坐标的荟萃分析，以识别 aMCI 中一致的 ReHo 改变。我们确定了 10 项研究，其中 11 个数据集适合纳入，包括 378 名 aMCI 患者和 435 名健康对照。该荟萃分析确定了 aMCI 患者相对于健康对照组的显着 ReHo 改变，主要在默认模式网络 (DMN) 内（双侧后扣带皮层 [PCC]、右角回、双侧颞中回和左侧海马旁回/海马), 执行控制网络（右顶叶上小叶和背外侧前额叶皮层）、视觉网络（右舌回和左枕中回）和感觉运动网络（右中央旁小叶/补充运动区、右中央后回和左后岛叶）。观察到双侧 PCC、左侧海马旁回/海马和右侧顶叶上小叶/角回的 ReHo 改变的显着异质性。探索性元回归分析表明，一般认知功能、性别分布、年龄和教育水平部分促成了这种异质性。本研究提供了 aMCI 与 DMN、执行控制网络、视觉网络和感觉运动网络内的异常 ReHo 相关的临时证据。这些局部功能连接性改变表明这些网络中功能缺陷和补偿并存。这些发现有助于大脑功能连接组的建模和更好地理解 aMCI 的神经基质。混杂因素值得关注，值得未来调查。