当前位置: X-MOL 学术J. Headache Pain › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme
The Journal of Headache and Pain ( IF 7.4 ) Pub Date : 2019-06-07 , DOI: 10.1186/s10194-019-1012-1
Kaname Ueda , Wenyu Ye , Louise Lombard , Atsushi Kuga , Yongin Kim , Sarah Cotton , James Jackson , Tamas Treuer

BackgroundIn Japan, detailed information on the characteristics, disease burden, and treatment patterns of people living with migraine is limited. The aim of this study was to compare clinical characteristics, disease burden, and treatment patterns in people with episodic migraine (EM) or chronic migraine (CM) using real-world data from clinical practice in Japan.MethodsThis was an analysis of data collected in 2014 by the Adelphi Migraine Disease Specific Programme, a cross-sectional survey of physicians and their consulting adult patients in Japan, using physician and patient questionnaires. We report patient demographics, prescribed treatment, work productivity, and quality-of-life data for people with CM (≥15 headache days/month) or EM (not fulfilling CM criteria). In descriptive analyses, continuous and categorical measures were assessed using t-tests and Chi-squared tests, respectively.ResultsPhysicians provided data for 977 patients (mean age 44.5 years; 77.2% female; 94.5% with EM, 5.5% with CM). A total of 634/977 (64.9%) invited patients (600 with EM; 34 with CM) also provided data. Acute therapy was currently being prescribed in 93.7% and 100% of patients with EM and CM, respectively (p = 0.069); corresponding percentages for current preventive therapy prescriptions were 40.5% and 68.5% (p < 0.001). According to physicians who provided data, preventive therapy was used at least once by significantly fewer patients with EM than with CM (42.3% vs. 68.5%, respectively; p < 0.001). Among patients who provided physicians with information on issues with their current therapy (acute therapy: n = 668 with EM, n = 38 with CM; preventive therapy: n = 295 with EM, n = 21 with CM), lack of efficacy was the most frequently identified problem (acute therapy: EM 35.3%, CM 39.5% [p = 0.833]; preventive therapy: EM 35.3%, CM 52.4% [p = 0.131]). Moderate-to-severe headache-related disability (Migraine Disability Assessment total score ≥ 11) was reported by significantly fewer patients with EM than with CM (21.0% vs. 60.0%, respectively; p < 0.001) among patients who provided data.ConclusionsPreventive treatment patterns in people with EM versus CM differ in Japan, with both types of migraine posing notable disease burdens. Our findings demonstrate that more effective migraine therapies are required to reduce the burden of the disease.

中文翻译:

日本偶发性和慢性偏头痛的真实治疗模式和患者报告结果:来自 Adelphi 偏头痛疾病特定项目的数据分析

背景在日本,关于偏头痛患者的特征、疾病负担和治疗模式的详细信息是有限的。本研究的目的是使用来自日本临床实践的真实数据比较发作性偏头痛 (EM) 或慢性偏头痛 (CM) 患者的临床特征、疾病负担和治疗模式。 2014 年由 Adelphi Migraine Disease Special Programme 发起,这是一项对日本医生及其咨询成年患者的横断面调查,使用医生和患者问卷调查。我们报告了 CM(头痛天数≥15 天/月)或 EM(不符合 CM 标准)患者的人口统计数据、规定的治疗、工作效率和生活质量数据。在描述性分析中,连续和分类测量分别使用 t 检验和卡方检验进行评估。结果医生提供了 977 名患者的数据(平均年龄 44.5 岁;77.2% 女性;94.5% 为 EM,5.5% 为 CM)。共有 634/977 (64.9%) 名受邀患者(600 名 EM;34 名 CM)也提供了数据。目前分别有 93.7% 和 100% 的 EM 和 CM 患者接受了急性治疗(p = 0.069);当前预防性治疗处方的相应百分比分别为 40.5% 和 68.5% (p < 0.001)。根据提供数据的医生,EM 患者至少使用一次预防性治疗的人数明显少于 CM 患者(分别为 42.3% 和 68.5%;p < 0.001)。在向医生提供有关当前治疗问题信息的患者中(急性治疗:EM 患者 n = 668,CM 患者 n = 38;预防性治疗:EM 患者 n = 295,CM 患者 n = 21),缺乏疗效是最常见的问题(急性治疗:EM 35.3%,CM 39.5% [p = 0.833];预防性治疗:EM 35.3%,CM 52.4% [p = 0.131])。在提供数据的患者中,EM 患者报告的中度至重度头痛相关残疾(偏头痛残疾评估总分 ≥ 11)明显少于 CM 患者(分别为 21.0% 和 60.0%;p < 0.001)。 EM 与 CM 患者的治疗模式在日本有所不同,两种类型的偏头痛都会造成显着的疾病负担。我们的研究结果表明,需要更有效的偏头痛疗法来减轻疾病负担。CM 39.5% [p = 0.833]; 预防性治疗:EM 35.3%,CM 52.4% [p = 0.131])。在提供数据的患者中,EM 患者报告的中度至重度头痛相关残疾(偏头痛残疾评估总分 ≥ 11)明显少于 CM 患者(分别为 21.0% 和 60.0%;p < 0.001)。 EM 与 CM 患者的治疗模式在日本有所不同,两种类型的偏头痛都会造成显着的疾病负担。我们的研究结果表明,需要更有效的偏头痛疗法来减轻疾病负担。CM 39.5% [p = 0.833]; 预防性治疗:EM 35.3%,CM 52.4% [p = 0.131])。在提供数据的患者中,EM 患者报告的中度至重度头痛相关残疾(偏头痛残疾评估总分 ≥ 11)明显少于 CM 患者(分别为 21.0% 和 60.0%;p < 0.001)。 EM 与 CM 患者的治疗模式在日本有所不同,两种类型的偏头痛都会造成显着的疾病负担。我们的研究结果表明,需要更有效的偏头痛疗法来减轻疾病负担。001)在提供数据的患者中。结论 EM 与 CM 患者的预防性治疗模式在日本不同,两种类型的偏头痛都构成显着的疾病负担。我们的研究结果表明,需要更有效的偏头痛疗法来减轻疾病负担。001)在提供数据的患者中。结论 EM 与 CM 患者的预防性治疗模式在日本不同,两种类型的偏头痛都构成显着的疾病负担。我们的研究结果表明,需要更有效的偏头痛疗法来减轻疾病负担。
更新日期:2019-06-07
down
wechat
bug