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Fluctuations of sensorimotor processing in migraine: a controlled longitudinal study of beta event related desynchronization
The Journal of Headache and Pain ( IF 7.4 ) Pub Date : 2019-07-09 , DOI: 10.1186/s10194-019-1026-8
Martin Syvertsen Mykland , Marte Helene Bjørk , Marit Stjern , Petter Moe Omland , Martin Uglem , Trond Sand

BackgroundThe migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other well-known premonitory CNS-symptoms. In the present study we measured EEG-activation to non-painful motor and sensorimotor tasks in the different phases of the migraine cycle by longitudinal measurements of beta event related desynchronization (beta-ERD).MethodsWe recorded electroencephalography (EEG) of 41 migraine patients and 31 healthy controls. Each subject underwent three EEG recordings on three different days with classification of each EEG recording according to the actual migraine phase. During each recording, subjects performed one motor and one sensorimotor task with the flexion-extension movement of the right wrist.ResultsMigraine patients had significantly increased beta-ERD and higher baseline beta power at the contralateral C3 electrode overlying the primary sensorimotor cortex in the preictal phase compared to the interictal phase. We found no significant differences in beta-ERD or baseline beta power between interictal migraineurs and controls.ConclusionIncreased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology.

中文翻译:

偏头痛感觉运动处理的波动:β事件相关去同步化的受控纵向研究

背景偏头痛的大脑似乎经历了感觉处理的周期性波动。例如,在发作前期,偏头痛患者会出现疼痛感知改变的症状和体征,以及其他众所周知的先兆性中枢神经系统症状。在本研究中,我们通过纵向测量 β 事件相关去同步化 (beta-ERD) 来测量偏头痛周期不同阶段对非疼痛性运动和感觉运动任务的 EEG 激活。方法我们记录了 41 名偏头痛患者的脑电图 (EEG) 和31 个健康对照。每个受试者在三个不同的日子里接受了三个 EEG 记录,每个 EEG 记录根据实际的偏头痛阶段进行分类。在每次录音期间,受试者通过右手腕的屈伸运动执行一项运动和一项感觉运动任务。结果与发作间期相比,偏头痛患者在发作前期的初级感觉运动皮层上的对侧 C3 电极的β-ERD 显着增加,基线β 功率更高。我们发现发作间期偏头痛患者和对照组之间的β-ERD 或基线β 功率没有显着差异。结论增加的发作前基线β 活性可能反映了感觉运动皮层预激活的减少。改变的预激活可能导致抑制反应阈值的变化和 β-ERD 反应的增加,这可能反映了偏头痛发作前皮质反应性的普遍增加。二级和三级传入躯体感觉神经元及其相关皮质和/或丘脑中间神经元活动的周期性波动,
更新日期:2019-07-09
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